glucokinase


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glucokinase

[¦glü·kō′kī‚nās]
(biochemistry)
An enzyme that catalyzes the phosphorylation ofD-glucose to glucose-6-phosphate.
References in periodicals archive ?
05) increased, whereas HDL, SOD, CAT, GSH and the glycolytic enzyme glucokinase levels were significantly (p < 0.
Biotin induces the enzyme glucokinase, which plays a role in the catabolism of glucose.
AMG 151 / ARRY-403 (Amgen) - Glucokinase activator for type 2 diabetes: Array completed a Phase 1 multiple ascending dose clinical trial in patients with type 2 diabetes with AMG 151 / ARRY-403, a small-molecule glucokinase activator that Array partnered with Amgen Inc.
MODY 2 patients have mutations in the glucokinase (hexokinase 4) (GCK) [3] gene, which decrease the affinity of this enzyme for glucose and thus shift glucose-regulated insulin secretion to a higher-than-normal glucose concentration.
2008), glucokinase (Km: 7-9 mM) and glucose transporter 2 (GLUT 2; Km: ~17 mM) are activated in the pancreas, causing the intracellular ATP level to increase.
It may reduce atherosclerotic lesions; and it modifies genomic expressions, for example, glucokinase.
Lilly Granted Exclusive Rights to Glucokinase Activator Program For The
In hepatocytes, insulin stimulates a rapid increase in transcription of the gene coding for sterol response-binding protein-lc, which has been implicated in the expression of lipogenic genes; moreover, cholesterol synthesis genes in hepatocytes include fatty acid synthase (Fasn), steroyl-coenzyme A desaturase (Scd1), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), glucokinase (Gk), and farnesyl diphosphate synthase (Fdps) (Yeagley et al.
We entered into a licensing agreement with TransTech Pharma for the development and commercialization of glucokinase activators, a novel class of glucose-lowering agents in early Phase II development for the treatment of diabetes.