gluconeogenesis


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Related to gluconeogenesis: Cori cycle

gluconeogenesis

[¦glü·kō¦nē·ō′jen·ə·səs]
(biochemistry)
Formation of glucose within the animal body from substances other than carbohydrates, particularly proteins and fats.
References in periodicals archive ?
Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus.
Sorghum, a grass plant eaten in Egypt some 4,000 years ago and now cultivated in Africa and Asia, complements the sugar control benefits of mulberry by further improving insulin sensitivity and reducing gluconeogenesis, the creation of excess sugar molecules in the liver.
Moreover, gluconeogenesis directly linked to urea cycle in liver was reduced by extract treatment.
Meanwhile, the intraperitoneal glucose tolerance test (IPGTT) was significantly decreased, with the increased capacity of gluconeogenesis.
Low glucokinase activity and high rates of gluconeogenesis contribute to hyperglycemia in barn owls (Tyto alba) after a glucose challenge.
Type 1 Diabetic patients who have Hypothyroidism have reduced rate of gluconeogenesis with an increased incidence of hypoglycaemia.
Conclusions: Consequently, marein improved insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3[beta] to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis.
In diabetic rats, there was an increase in gluconeogenesis and a decrease in glycolysis.
The investigators also found that dapagliflozin treatment further promotes glucagon secretion and hepatic gluconeogenesis in healthy mice, thereby limiting the decrease of plasma glucose induced by fasting.
However, during T2D the hepatic glucose uptake is reduced while rates of gluconeogenesis and lipogenesis are increased.
Metformin is an oral antidiabetic drug which shows its effects by inhibition of hepatic gluconeogenesis, enhancing peripheral glucose uptake, decreasing insulin resistance and hepatic glucose output.
Increased gluconeogenesis - the manufacture of blood sugar and the thermic effect of proteins.