glucose-6-phosphate dehydrogenase


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Related to glucose-6-phosphate dehydrogenase: pentose phosphate pathway, glucose-6-phosphate dehydrogenase test

glucose-6-phosphate dehydrogenase

[′glü‚kōs ¦siks ′fäs‚fāt dē‚hī′drä·jə‚nās]
(biochemistry)
The mammalian enzyme that catalyzes the oxidation of glucose-6-phosphate by TPN+(triphosphopyridine nucleotide).
References in periodicals archive ?
Genetic heterogeneity at the glucose-6-phosphate dehydrogenase locus in southern Italy: a studyon a population from the Matera district.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency on the other hand is the most common enzymopathy of humans (5).
Fructose-1,6-diphosphatase, phosphofructokinase and glucose-6-phosphate dehydrogenase from fermenting and non fermenting yeasts.
Its failure to combat cyanosis should suggest the possibility of glucose-6-phosphate dehydrogenase (G6PD) deficiency or nicotinamide-adenine dinucleotide phosphate, reduced form (NADPH)-methaemoglobin reductase deficiency (3).
Determination of glucose-6-phosphate dehydrogenase deficiency: comparision of three methods.
His glucose-6-phosphate dehydrogenase level was within reference range.
The activities of hexokinase, glucose-6-phosphatase, fructose-1,6- bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase were measured.
Trametinib in combination with dabrafenib can cause serious side effects, some of which can be life threatening, including: new primary cutaneous malignancies (new skin cancers); tumour promotion in wild-type BRAF melanoma; haemorrhagic events (symptomatic bleeding in a critical area or organ); venous thromboembolic events (blood clots); cardiomyopathy (heart problems, including heart failure); ocular (eye-related) toxicities; interstitial lung disease (ILD); serious febrile drug reactions (severe fevers); serious skin toxicity (rash); hyperglycaemia (blood sugar problems); haemolytic anaemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency; and embryofoetal toxicity (potential harm to the unborn baby in pregnant women).
Akar suggested that oseltamivir might be used safely in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency (1).
Malaria has also been hypothesized as the evolutionary driving force behind sickle-cell disease, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and other erythrocyte defects like Duffy null phenotype (4).
Glucose-6-phosphate dehydrogenase and isocitrate dehydrogenase, which provide reduced nicotinamide adenine dinucleotide phosphate (NADPH), also showed higher activity in the epidermis than the dermis by 111% and 313%, respectively.
However, Cameron and Hoffer did not report that they followed the precautions in step 5, regarding the deficiency of glucose-6-phosphate dehydrogenase enzyme, or step 6.

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