Glucuronic Acid


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glucuronic acid

[¦glü·kyə¦rän·ik ′as·əd]
(biochemistry)
C6H10O7 An acid resulting from oxidation of the CH2OH radical ofD-glucose to COOH; a component of many polysaccharides and certain vegetable gums. Also known as glycuronic acid.

Glucuronic Acid

 

one of the uronic acids, COH(CHOH)4COOH; it is formed in the body from glucose when the latter is oxidized by a primary alcohol group. It is optically active and dissolves readily in water. Melting point, 167°-172° C. D-glucuronic acid is widespread in the animal and vegetable worlds and is a component of acid mucopolysaccharides, some bacterial polysaccharides, triterpenoid saponins, hemicellulose, and gums. Free glucuronic acid is found in blood and urine in small quantities. Certain metabolic products, including some toxic products (phenol and cresol), as well as many medications, are discharged with the urine in the form of sister compounds of glucuronic acid (glucuronides). Conversions of glucuronic acid in all animals except the monkey and guinea pig, as well as in humans, lead to the biosynthesis of ascorbic acid. Body fluids and tissues of animals (especially the liver, kidneys, and spleen, and also malignant tumors) and bacterial and plant tissues contain the enzyme β-glucuronidase, which catalyzes the hydrolysis of β-glucuronides to free glucuronic acid and the corresponding aglycon.

G. A. SOLOV’EVA

References in periodicals archive ?
These were glucuronic acid, Nacetylglucosamine, and potato starch.
We believe rather that depletion of glucuronic acid by DPH most likely increased the hepatotoxicity of TMP-SMZ, resulting in acute fulminant hepatic failure.
We predicted that Mojave woodrats would excrete more glucuronic acid per unit dry mass of resin consumed.
050 was generated by the neutral loss of one glucuronic acid molecule, and the other fragment ions were identical to those of WEL (Fig.
The uronic acid content of the SP fractions was determined by carbazole-sulfuric acid method using spectrophotometric analysis (AMERSHAM BIOSCIENCES ULTROSPEC 1100) at 525 nm, using glucuronic acid as standard.
13) When HA is digested with hyaluronidase, the final reaction products are found to contain mainly tetrasaccharides and hexasaccharides, which have N-acetylglucosamine at the reducing termini and glucuronic acid at the non-reducing termini.
In the body, the two sugar molecules are split off by the enzyme beta glucosidase (probably by bacteria in the colon) and are replaced by a glucuronic acid molecule to form a compound consisting of glucuronic acid bound to mandelonitrile (the benzaldehyde-cyanide radical).
VPA is normally metabolized by the liver via glucuronic acid conjugation, mitochondrial [beta]-oxidation, and cytoplasmic [omega]-oxidation (Fig.
Albumin transports unconjugated bilirubin to the liver where it is metabolized using glucuronic acid into direct bilirubin.
He said that in this brave new world, chefs would shun vegetables, such as carrots, and would instead use the molecules, which make up carrots - caroteniods, pectins, fructose and glucuronic acid - instead.
EtG is another minor metabolite of alcohol that forms in the liver when alcohol reacts with glucuronic acid, a substance which works to detoxify drugs by turning them into water-soluble compounds that can be easily removed from the body.
Other GAGs containing glucuronic acid, such as heparin, or even free glucuronic acid on its own, will have the same response as chondroitin.