glucuronidase


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glucuronidase

[‚glü·kyə′rän·ə‚dās]
(biochemistry)
An enzyme that catalyzes hydrolysis of glucuronides. Also known as glycuronidase.
References in periodicals archive ?
Like several other benzodiazepines, in human body, diazepam undergoes hepatic phase I and II metabolism mediated by cytochrome P450s system (CYPs) and glucuronidase, and generates several pharmacologically active metabolites.
Excess glucuronidase activity means more of the toxins are liberated from glucuronic acid, getting reabsorbed into the body instead of being led out.
Excretion ratios to doses until 8 hr for OX, 5-CHQ, and DCHQ and until 10 hr for ICHQ are expressed as per cent dose Table 3: Hydrolysis Rate Constants catalyzed by [beta]- Glucuronidase and Arylsulfatase in Rat Liver and Kidney Fraction Tissue Liver Mitochondrial- Microsome Lysosome [beta]-Glucuronidase OX 0.
The TaqMan gene expression assay for EGFR and the endogenous control glucuronidase beta (GUSB) were obtained from Applied Biosystems.
To circumvent the unintended intestinal toxicity of SN38, researchers developed an inhibitor of microbial glucuronidase that was not toxic to gut microbes, but which prevented the metabolism of SN38G and thereby increased mouse tolerance to CPT-11 (Wallace et al.
75 Table 3 Effect of ethanol extract of plant samples on the activity of trypsin induced hydrolysis of BSA, [beta]-glucuronidase and PPO [beta]- Sr No Name of plant Trypsin glucuronidase PPO [IC.
5 ml of plasma, was incubated with 6 ml of enzyme sulphatase (Sigma, USA, 23 units) and glucuronidase (Sigma, USA, 3.
Control by sugars and diols of the immunological effect of beta glucuronidase in mice and patients with hay fever.
The scientists also inserted into some of the cells a gene to make more beta- glucuronidase, but it's unclear to what extent the gene boosted enzyme production.
Additionally, elevated beta glucuronidase enzyme activity has been associated with the level of hormone receptors that control the amount of estrogen, progesterone and other sex related hormones in the body.
In clinical specimens, glucuronidase can be used to increase positivity in assays designed to detect the parent compound, not the conjugated metabolite, by removing the glucuronide.
Among these, [beta]-glucuronidase is of interest because it is the enzyme that hydrolyses biliary glucuronidases when they reach the colon (duWollowski et al.