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glucuronide

   Also found in: Medical, Wikipedia 0.01 sec.
glucuronide [glü′kyu̇r·ə‚nīd]
(biochemistry)
A compound resulting from the interaction of glucuronic acid with a phenol, an alcohol, or an acid containing a carboxyl group. Also known as glycuronide.
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Human experimental studies of bisphenol A (BPA) metabolism have reported rapid clearance of the hormonally active parent compound via glucuronide conjugation followed by urinary excretion of the inactive conjugated metabolite.
BPA metabolism and human risk assessment by Environmental Health Perspectives
Instead of being excreted via the gut, the metabolites may be hydrolysed by enzymatic activity of the gut bacteria (principally Clostridium species) to liberate active ethinyloestradiol from the sulphate and glucuronide groups.
Combined oral contraception and broad-spectrum antibiotic use by Decloedt, Eric; Blockman, Marc / CME: Your SA Journal of CPD
Figure 4 shows extracted ion chromatograms (XIC) that were generated relating to the ketone glucuronide (m/z 411), glucuronide (m/z 381) and hydroxyglucuronide (m/z 397) metabolites.
Novel mass spec to detect metabolites during drug quantification: ... by Rainville, Paul D.; Castro-Perez, Jose; Mather, Joanne / Pharma
 
 
 
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