glutaminase


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glutaminase

[glü′tam·ə‚nās]
(biochemistry)
The enzyme which catalyzes the conversion of glutamine to glutamic acid and ammonia.
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This novel assay allows us to directly measure the inhibition of glutaminase in both tumors and in platelets from peripheral blood.
After discovering that 968 inhibited glutaminase and effectively shrunk tumor cells, Cerione and his research team tested the molecule to understand its effects on non-cancerous cells.
Effects of prolonged administration of Diamox on excretion of acid and carbonic anhydrase and glutaminase activities in the kidney.
et al, in regards to zeta-crystallin and glutaminase interactions and expression of the glutaminase(GA) mRNA, under conditions mimicking normal and acidotic physiology's.
Case Study: Structure-Function Studies of a Glutaminase Inhibitor Complex
During a minisymposium session on cancer metabolism, Calithera will report on the development of novel pharmacodynamic assays that will be applied to the company's clinical studies to measure glutaminase inhibition in patients following administration of CB-839.
19) 105 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha 106 Stress-induced-phosphoprotein 1 (STI1) 107 Glutaminase kidney isoform, mitochondrial precursor (GLS) 108 Retinal dehydrogenase 1 (EC 1.
Maintaining the optimal pH was very important operational requirement for maximizing the yield of L-glutaminase production because the bacterial activity and properties of glutaminase to separation were strongly dependent on Ph [8].
This is a protease preparation containing endo-, exopeptidase and glutaminase that can be used to hydrolyse proteins such as wheat and soya.
Scientists at Rutgers University evaluated the flavor profile of gluten treated with a combination of protease and glutaminase and then heated with glucose.
At the AACR meeting today, a poster titled "X-Ray structure of human glutaminase in complex with BPTES and analysis of BPTES-resistant mutants" (Abstract 3237) was presented, showing the first reported crystal structure of glutaminase bound with the compound BPTES.
CB-839 is a potent, selective, orally bioavailable glutaminase inhibitor that interferes with tumor metabolism and blocks cancer cell growth and survival.

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