glutaminase


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glutaminase

[glü′tam·ə‚nās]
(biochemistry)
The enzyme which catalyzes the conversion of glutamine to glutamic acid and ammonia.
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This represents one of several strategies to develop CB-839, a glutaminase inhibitor, in combination with approved therapies with the hope of improving the treatment of patients with solid tumors.
Alongside its demonstrated potential as an antileukemic agent, glutaminase is generally regarded as a key enzyme in controlling the taste of fermented foods such as soy sauce, especially in Asian countries.
Speranza, Ph-Dependent Hydrolase, Glutaminase, Transpeptidase and Autotranspeptidase Activities of Bacillus subtilis g-Glutamyltransferase, Febs.
The company said the Phase 1/2 clinical trial is assessing the safety and efficacy of CB-839, a first-in-class glutaminase inhibitor, in combination with nivolumab for the treatment of renal cell carcinoma, malignant melanoma and non-small cell lung cancer.
In this biochemical process, the glutaminase enzyme catalyzes the glutamine hydrolysis and leads to the synthesis of ammonia and glutamate (Meister, 1980) or, the glutamine synthase enzyme catalyzes the conversion of glutamine from glutamate and ammonia in presence of ATP (Borges et al.
Higher concentrations of molybdenum ions in body fluids were reported to inhibit the production of succinate oxidase, sulfite oxidase, glutaminase, cholinesterase, cytochrom oxidase, superoxide dismutase, and other enzymes [8,9] and to interfere with the normal metabolism of copper [10].
Food Standards Australia New Zealand (FSANZ) today called for submissions on an application to use glutaminase sourced from Bacillus amyloliquefaciens as a processing aid.
Notably, LON activity is not limited to misfolded and/or damaged proteins since several other proteins have been identified as LON substrates under normal conditions, including succinate dehydrogenase subunit 5, glutaminase C, cystathionine [beta]-synthase, and cytochrome c oxidase subunit 4 isoform 1 [59-62].
The tissue trans glutaminase (TTG) antibody test and endomysial antibodies (TTG IgA-0.
In general it contributes to the release of some hormones elevates the activity of intestinal glutaminase stimulates the pancreas and choleresis resists the oxidative injury of oxygen free radicals to biomembrane and increases the survival rate of cells.

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