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(glī`kəjən), starchlike polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) that is found in the liver and muscles of humans and the higher animals and in the cells of the lower animals. Chemically it is a highly branched condensation polymer of glucoseglucose,
or grape sugar,
monosaccharide sugar with the empirical formula C6H12O6 . This carbohydrate occurs in the sap of most plants and in the juice of grapes and other fruits.
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; it is readily hydrolyzed to glucose. Glycogen is formed by the liverliver,
largest glandular organ of the body, weighing about 3 lb (1.36 kg). It is reddish brown in color and is divided into four lobes of unequal size and shape. The liver lies on the right side of the abdominal cavity beneath the diaphragm.
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 from glucose in the bloodstream and is stored in the liver; conversion of glucose to glycogen (glycogenesis) and hydrolysishydrolysis
, chemical reaction of a compound with water, usually resulting in the formation of one or more new compounds. The most common hydrolysis occurs when a salt of a weak acid or weak base (or both) is dissolved in water.
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 of glycogen to glucose (glycogenolysis) together are the usual mechanism for maintenance of normal levels of blood sugar. Glycogen is also produced by and stored in muscle cells; during short periods of strenuous activity, energy is released in the muscles by direct conversion of glycogen to lactic acid. During normal activity, energy is released by metabolic oxidation of glucose to lactic acid.


The primary reserve polysaccharide of the animal kingdom. It is found in the muscles and livers of all higher animals, as well as in the cells of lower animals. Because of its close relationship to starch, it is often called animal starch, although glycogen is found in some lower plants, fungi, yeast, and bacteria. See Starch

Glycogen is a nonreducing, white, amorphous polysaccharide which dissolves readily in cold water, forming an opalescent, colloidal solution. The molecular weight of glycogen is usually very high, and it varies with the source and the method of preparation; molecular weights of the order of 1-20 × 106 have been reported. Chemical studies show glycogen to possess a branched structure similar to the amylopectin starch fraction.

In its biochemical reactions, glycogen is similar to starch. It is attacked by the same plant amylases that attack starch, and like starch, it is degraded to maltose and dextrins. Both glycogen and starch are broken down by animal or plant phosphorylase enzyme in the presence of inorganic phosphate with the production of α- d -glucose-1-phosphate. See Carbohydrate metabolism

The metabolic formation of glycogen from glucose in the liver is frequently termed glycogenesis. In fasted animals, glycogen formation can be induced by the feeding, not only of materials that can be hydrolyzed to glucose and other monosaccharides, such as fructose, but also of various other materials. A number of l -amino acids, such as alanine, serine, and glutamic acid, upon deamination in the liver give rise to substances, such as pyruvic acid and α-ketoglutaric acid, that can be converted in the liver to glucose units which are subsequently converted to glycogen. Furthermore, substances such as glycerol derived from fats, dihydroxyacetone, or lactic acid can all be utilized for glycogen synthesis in the liver. Such noncarbohydrate precursors are termed glycogenic compounds. The process of glycogen formation from these precursors is known as glyconeogenesis. The term glycogenolysis is used to connote glycogen breakdown. See Polysaccharide



(also called animal starch), (C6H10O5)n, the basic reserve carbohydrate of animals and man; also found in some bacteria, yeasts, and fungi. Its content is particularly high in the liver (3-5 percent) and muscles (0.4-2 percent). Glycogen was discovered by the French physiologist

Figure 1. Diagram of a molecule of glycogen: A is the “aldehyde” origin of the chain; the small circles are glucose radicals. The boundaries of β-dextrin are shown by the dotted line, and the quadrangle is the part of the molecule whose formula is given in Figure 2.

C. Bernard in the liver (1857). Glycogen is a homopolysaccharide consisting of 6,000-20,000 or more α-D-glucose radicals. The glycogen molecule has a branched structure; the average length of the unbranched chain is 10-14 glucose radicals (see Figures 1 and 2). The molecular weight of glycogen is 105-107.

Glycogen is a white amorphous powder that is polydisperse

Figure 2. Part of a glycogen molecule; the glucose radicals are joined by 1,4-glycoside bonds and, at the branching point, by a 1,6-glycoside bond.

and opalescent in solution. It is optically active ([α]D = + 198°). Glycogen solutions containing iodine exhibit colors varying from violet-brown to violet-red. Glycogen is split in two ways in the organism. Hydrolytic splitting of the glycogen contained in food occurs during the digestive process with the participation of amylases. The processes starts in the oral cavity and ends in the small intestine (at pH 7-8), leading to the formation of dextrins and then of maltose and glucose. Glucose enters the bloodstream, and the excess glucose participates in the synthesis of glycogen, in the form of which it is deposited in the tissues. Hydrolytic splitting of glycogen is also possible in tissue cells, but this process is of lesser importance. The main path of intracellular glycogen transformation is phosphorolytic splitting, which occurs under the influence of phosphorylase and leads to sequential splitting off of glucose units from the glycogen molecule, accompanied by their simultaneous phosphorylation. The glucose-1-phosphate formed in this case, may be included in the glycogenolysis process. The phosphorylation of glucose is a mandatory stage of glycogen synthesis. The synthesis takes place with the participation of the enzyme glycogen synthetase. Cytoplasm contains glycogen in the form of polysaccharides of various molecular weights and with a variety of physicochemical properties. The composition of glycogen may vary depending on the functional state of the tissue, the season of the year, and other factors.

The glycogen content of tissues depends on the activity ratio of phosphorylase and glycogen synthetase, as well as on the tissue’s glucose supply from the blood. Lowering the blood sugar leads to a high phosphorylase activity, and so-called glycogen mobilization takes place, accompanied by its disappearance from the cytoplasm. Conversely, glycogen synthesis predominates in cases of enrichment of the blood with glucose (for example, after the intake of food). An important function in maintaining a constant blood-sugar level is performed by the liver, which either transforms the glucose excess into glycogen or mobilizes the excess glucose in case of a sugar deficiency in the blood. Other organs store glycogen for their own consumption. In this case, glucose entering the cell is usually utilized in the synthesis of glycogen, which is subsequently consumed as the basic substrate in anaerobic carbohydrate transformations. An important role in regulating the blood-sugar content is played by the central nervous system. The brain tissue contains little glycogen, and therefore fluctuations in the blood-sugar level are reflected in the metabolic processes in the brain. The direction of glycogen exchange in the liver is controlled by biologically active materials with the participation of the hypothalamus and the sympathetic nervous system. The most important are the hormones adrenalin and glucagon (which cause the mobilization of glycogen), as well as insulin, which stimulates its synthesis.


Khimiia uglevodov. Moscow, 1967.



A nonreducing, white, amorphous polysaccharide found as a reserve carbohydrate stored in muscle and liver cells of all higher animals, as well as in cells of lower animals.


a polysaccharide consisting of glucose units: the form in which carbohydrate is stored in the liver and muscles in man and animals. It can easily be hydrolysed to glucose
References in periodicals archive ?
Glycogen content of muscle was measured via the method described by Dreiling et al.
Brent Ruby, director of UM's Montana Center for Work Physiology and Exercise Metabolism, graduate student Michael Cramer, and a team of researchers in UM's Department of Health and Human Performance detailed these findings in a paper titled "Post-exercise Glycogen Recovery and Exercise Performance is Not Significantly Different Between Fast Food and Sport Supplements.
The researchers conservatively estimate that about one in 2,500 people in Nunavik may have glycogen storage disease type Ilia.
The glycogen concentrations in the hepatopancreas and muscle homogenates were measured as follows (Dubois et al.
It's entirely possible, then, to run out of glycogen and continue to produce ATP aerobically.
The increase in information about glycogen storage disease 1a and GSD 1b and in the rate of determination of mutation gave the idea of diagnosing GSD 1a and GSD 1b with mutation analysis together with clinical and biochemical abnormalities instead of enyzmatic measurement by liver biopsy which is an invasive method.
Glycogen is essentially a long chain of glucose (blood sugar).
The expression of intramuscular interleukin-6 and release of muscle proteins will increase when the intramuscular glycogen is in critical situation.
The question for clinicians should be, is the glycogen loading philosophy the smartest thing for your weight-loss patients?
Glycogen is a vital fuel source for high intensity and prolonged exercise, and the dependence of this energy substrate increases as exercise intensity rises (Bergstrom and Hultman, 1966; 1967).
A small window of opportunity exists where cells within the skeletal muscle are more susceptible and prone to receiving vital nutrients that replenish glycogen reserves, the fuel stored in muscles.