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glycolytic pathway

   Also found in: Dictionary/thesaurus, Medical, Wikipedia, Hutchinson 0.02 sec.

glycolysis

 or glycolytic pathway or Embden-Meyerhof-Parnas pathway

Sequence of 10 chemical reactions taking place in most cells that breaks down glucose, releasing energy that is then captured and stored in ATP. One molecule of glucose (plus coenzymes and inorganic phosphate) makes two molecules of pyruvate (or pyruvic acid) and two molecules of ATP. The pyruvate enters into the tricarboxylic acid cycle if enough oxygen is present or is fermented into lactic acid or ethanol if not. Thus, glycolysis produces both ATP for cellular energy requirements and building blocks for synthesis of other cellular products. See also Gustav Georg Embden, Otto Meyerhof.


glycolytic pathway [¦glī·kə¦lid·ik ′path‚wā]
(biochemistry)
The principal series of phosphorylative reactions involved in pyruvic acid production in phosphorylative fermentations. Also known as Embden-Meyerhof pathway; hexose diphosphate pathway.


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Lactate dehydrogenase (LDH) is the last enzyme of the glycolytic pathway and catalyzes the conversion of pyruvate to lactate (forward; LDHf) or lactate to pyruvate (reverse; LDHr).
When oxygenation reaches low critical levels, conservative strategies favor reversible inhibition of the glycolytic pathway, coupled with additional substrate-level phosphorylations (Hochachka & Somero 2002).
Common sense dictates that without proper blood flow, there will not be efficient delivery of oxygen to tissues, and without oxygen, tissues are forced through glycolytic pathways to maintain function.
 
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