glycosylation


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glycosylation

[glī‚käs·ə′lā·shən]
(biochemistry)
A chemical reaction in which glycosyl groups are added to a protein to produce a glycoprotein.
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References in periodicals archive ?
N-linked glycosylation in the hemagglutinin of influenza A viruses.
In their studies, Hsieh-Wilson's team found that this glycosylation -- the addition of GlcNAc to PFK1 -- is enhanced under conditions associated with tumors, such as low oxygen levels.
Glythera Limited is a biotechnology company specialising in the development of enhanced protein/peptide therapeutics through the use of advanced glycosylation and conjugation technologies.
Knowing the protein glycosylation status in wine will help us understand various processes.
For instance, the measurement of thyroid-stimulating hormone is complicated by altered glycosylation as a function of the state of the thyroid (12), and gastrin is affected by disease-dependent molecular heterogeneityin the plasma (13, 14).
We have not attempted to dissect the causative agent for this effect but we have identified (data not shown) that cell surface glycosylation patterns are also influenced by FBS concentrations, particularly the synthesis of 2-0-linked [alpha]-L-fucosyl units.
The researchers have discovered that the gene SRD5A3 is responsible for the synthesis of a lipid used by cells as a sugar carrier for protein glycosylation in which proteins are modified by the addition of a sugar or sugar chain.
In order to identify role of glycosylation glycan motifs of several native, deglycosylated native forms and non-glycosylated recombinant forms of ML were compared quantitatively.
Glycosylation patterns of recombinant proteins are relevant for the immunogenicity, the pharmacological activity, pharmacokinetic profile, solubility and stability of the protein.
MX-3253 (celgosivir) is an alpha-glucosidase I inhibitor and is currently the only oral anti-HCV drug in clinical development that acts through host- directed glycosylation.
By using Seikagaku's proprietary assay method and DPI's exclusive screening system, the two companies have discovered the compound candidates that inhibit the activity of glycosylation enzymes.
GlycoFi is the leader in the area of glycosylation engineering in living systems, and its patented, scaleable technology uniquely allows its partners to create specific human glycosylation variants of any therapeutic glycoprotein.

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