Technical advances in genetically altering laboratory mice to mimic human disease made it possible for the scientists to generate animals with a specific molecular disruption in dentate gyrus granule cells
Dentate granule cell
neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus.
Pax6 regulates granule cell
polarization during parallel fiber formation in the developing cerebellum.
Neonatal hypothyroidism also reduces the number of dentate gyrus granule cells
(46) and impairs their dendritic arborization (42,47).
There, the granule cells
inhibit the neurons that receive sensory inputs.
The granule cells
appeared to undergo serotonin-dependent 'dematuration', which increased their activity and reversed adult-type plasticity into an immature state.
Primary cultures of cerebellar neurons enriched in granule cells
were prepared from cerebella of 8-d-old SD rats as previously reported (Han et al.
2+] homeostasis, increasing its intracellular level in a number of experimental situations, including primary culture of cerebellar granule cells
SDF-1, a chemokine with a G protein coupled receptor, or BDNF, act as chemoattractants for cerebellar granule cells
, with SDF-1 action being selectively inhibited by soluble EphB receptor.
Maturation and Functional Integration of New Granule Cells
into the Adult Hippocampus
By demonstrating that the same neural circuits also can store information about context, the new study will likely increase the focus on these potential "memory cells" in the hippocampus, called semilunar granule cells
, said Dr.
They consist of axons of granule cells
of the dentate gyrus and show an age-dependent loss as do the granule cells
of the dentate gyrus.