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guanosine

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.04 sec.
guanosine [′gwän·ə‚sēn]
(biochemistry)
C10H13O5N5Guanine riboside, a nucleoside composed of guanine and ribose. Also known as vernine.


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The mutation leads to a loss of guanosine triphosphatase activity and thus to adenyl cyclase overactivity and subsequent overproduction of cyclic adenosine monophosphate (cAMP).
8-OHdG is formed in a promutagenic DNA lesion induced by the reaction of hydroxyl radicals with guanosine at the C8 site in DNA (Kasai et al.
This same biosynthetic pathway (mevalonate production) leads to the prenylation, or activation, of regulatory proteins such as guanosine triphosphate (GTP)-binding proteins.
 
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