References in periodicals archive ?
A genetic analysis of the pteridine biosynthetic enzyme, guanosine triphosphate cyclohydrolase, in Drosophila melanogaster.
DELFIA(R) GTP Binding Assay kit, the first non-radiometric platform for - guanosine triphosphate (GTP) binding; Image FlashPlate(TM), a new red-emission technology for a wide range of high throughput screening (HTS) imagers; and britelite(TM) and steadylite HTS(TM), breakthrough luminescence technologies for G-protein coupled receptor (GPCR) functional screening applications.
AVN944 is an oral small molecule drug candidate that inhibits inosine monophospate dehydrogenase (IMPDH), an enzyme that is critical for cells to be able to synthesize guanosine triphosphate (GTP), a molecule required for DNA synthesis and cellular signaling.
AVN944 is a potent inhibitor of cancer cell proliferation and elicits a specific set of cellular responses directly related to depletion of cellular guanosine triphosphate (GTP) pools.