Hemoglobinuria

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Related to haemoglobinuria: Paroxysmal hemoglobinuria, haemoglobinaemia, Haemosiderinuria

hemoglobinuria

[‚hē·mə‚glō·bə′nu̇r·ē·ə]
(medicine)
A pathological condition in which the urine contains hemoglobin.

Hemoglobinuria

 

the presence of hemoglobin in urine. It usually is a result of the intravascular decomposition of red blood cells following the transfusion of incompatible blood, the effect of some chemical and biological poisons and drugs that cannot be tolerated or of any of several causative agents of infections, extensive injuries, and so on.

References in periodicals archive ?
In 2008 doctors told him he has Paroxysmal Nocturnal Haemoglobinuria, which kills a third of patients within five years of diagnosis.
The reported severe manifestations included cerebral malaria, hepatic dysfunction, renal dysfunction, severe anaemia, ARDS, shock, pulmonary edema, haemoglobinuria, hypoglycemia and multiple organ involvement, along with thrombocytopenia which has also been included in many previous similar studies from all over the world (5-31).
Prevalence and Prognosis of Paroxysmal Nocturnal Haemoglobinuria and the Clinical and Cost-effectiveness of Eculizumab.
Acute renal failure may be caused by haemorrhage, ischaemia resulting from hypotension, effects of blood clotting abnormalities, renal vasoconstriction, pigment nephropathy caused by haemoglobinuria or myoglobinuria, direct nephrotoxicity and immune complex glomerulonephritis caused by serum sickness reactions to antivenom.
For 33-year-old John Duggan, who suffers from rare blood disorder Paroxysmal Nocturnal Haemoglobinuria, his life is priceless.
Thus, it can be postulated that hyperparasitization of young RBCs with increased sequestration in vital organs, haemolysis, haemoglobinuria and release of haemozoin pigment directly or indirectly lead to release of inflammatory mediators, causing damage to the structure and function of the organ including kidneys.