hemosiderin

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Related to haemosiderin: hemosiderosis

hemosiderin

[‚hē·mō′sid·ə·rən]
(biochemistry)
An iron-containing glycoprotein found in most tissues and especially in liver.
References in periodicals archive ?
Venous-related skin changes may also develop, including hyperpigmentation in the perimalleolar region secondary to haemosiderin deposition, lipodermatosclerosis with scarring, thickening of the skin secondary to fibrosis in the dermis and subcutaneous fatty tissue, and atrophie blanche characterised by circular whitish and atrophic skin surrounded by dilated capillaries and hyperpigmentation.
A low intensity signal on MRI may be found in only few cases all on sequences due to haemosiderin deposits.
For example, ferrous or ferric iron shortens T1 and T2 signal, methaemoglobin causes an increased T1 signal and variable T2 signal whereas haemosiderin decreases T1 and T2 signal.
Iron is also stored in an insoluble form in a poorly defined storage protein, haemosiderin, presumed to be derived from the lysosomal degradation of ferritin.
Also, KS lesions that have completely responded to therapy sometimes remain as hyperpigmented areas, presumably from haemosiderin deposits.