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haplo-insufficiency |
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haplo-insufficiency [¦hap‚lō ′in·sə‚fish·ən·sē] (genetics) In a diploid organism, the presence of an abnormal phenotype in which only one of the two copies of a particular gene yields its normal product, and a reduced amount rather than a qualitative change in the gene product leads to the phenotype. It is responsible for some, but not all, autosomal dominant disorders. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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