chancre(redirected from hard ulcer)
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, contagious sexually transmitted disease caused by the spirochete Treponema pallidum (described by Fritz Schaudinn and Erich Hoffmann in 1905). Syphilis was not widely recognized until an epidemic in Europe at the end of the 15th cent.
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A lesion or ulcer at the site of primary inoculation by an infecting organism.
The initial lesion of syphilis.
Pathol a small hard nodular growth, which is the first diagnostic sign of acquired syphilis