heavy chain


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Related to heavy chain: light chain, heavy chain disease

heavy chain

[′hev·ē ′chān]
(immunology)
The heavier of the two types of polypeptide chains occurring in immunoglobulin molecules, its molecular weight range being 50,000-70,000. Also known as A chain; H chain.
References in periodicals archive ?
The identified proteins were conglutinin precursor, bovine fibrinogen, IgG1 heavy chain constant region, hemoglobin, complement component 3 and IgG2a heavy chain constant region.
The antibodies will be directed against the C-terminus of the heavy chain and the light chain of each of these three BoNTs, as these domains contain neutralizing epitopes, according to the latest scientific data.
By late afternoon, once volunteers thought the vehicle was in shallower, calmer water, scuba divers Thomas Ridder and Matt Conrad were asked to attach a heavy chain with a locking ring to the KIA's rear axle.
The ferritin heavy chain converts the more unstable form of iron (Fe2+ or the ferrous) to a more stable (Fe3+ or the ferric) form that can be the safely sequestered and deposited within the ferritin shell.
For antibodies intended for therapeutic use or sequencing the N-terminals of the heavy chain and the light chain using protein sequencing methods to confirm the cDNA sequences cloned from hybridoma cell lines, you can contact info@Creative-Biolabs.
Wu Yuanhong, 42, was shown sitting on blankets in the narrow enclosure, his feet shackled with a heavy chain and wearing only a T-shirt and his underwear.
Molecular characterization of heavy chain immunoglobulin gene rearrangements in Waldenstrom's macroglobulinemia and IgM monoclonal gammopathy of undetermined significance.
B cell development within the Crescendo Mouse is driven from a construct introduced into the TKO background that combines human V- D- and J- genes, together with murine constant and regulatory regions, to generate heavy chain only antibodies.
He came awake to find himself lying on a thin pallet of straw, his hurts roughly bandaged and a heavy chain round his ankles.
Nikolay Mihaylov, goalkeeper of Bulgaria's national football team, was involved in a heavy chain car accident that took place on his home country's Trakiya highway, according to a media report.
This nephelometric assay uses antibodies specific for the intersection of the heavy and light chain of each immunoglobulin and allows separate quantification of each immunoglobulin heavy chain and light chain combination (e.