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heparin

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heparin (hĕp`ərĭn), anticoagulant anticoagulant , any of several substances that inhibit blood clot formation (see blood clotting). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance,
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 produced by cells in many animals. A polysaccharide, heparin is found in the human body and occurs in greatest concentration in the tissues surrounding the capillaries of the lungs and the liver. The substance, extracted from animal tissues, is used clinically to delay blood clotting blood clotting, process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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heparin

Naturally occurring mixture of organic compounds used as a short-term anticoagulant to prevent thrombosis during and after surgery and for initial treatment of various heart, lung, and circulatory disorders in which there is increased risk of blood clotting. Comprising complex carbohydrate molecules called mucopolysaccharides, it normally is present in the human body in liver and lung tissues. It was discovered in 1922 and originally used to prevent clotting in blood taken for laboratory tests.


heparin [′hep·ə·rən]
(biochemistry)
An acid mucopolysaccharide acting as an antithrombin, antithromboplastin, and antiplatelet factor to prolong the clotting time of whole blood; occurs in a variety of tissues, most abundantly in liver.


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Published in CMAJ (Canadian Medical Association Journal), the study looked at 320 patients undergoing heparin injections over 12 months at The Hospital of The Johann Wolfgang Goethe University in Frankfurt, Germany.
The assay is an ELISA-based screening test that addresses heparin-induced thrombocytopenia, an infrequent but potentially serious complication of heparin therapy.
In April 2008, FDA learned that 19 lots of heparin sodium were contaminated with Over-Sulfated Chondroitin Sulfate (OSCS), and these lots were later determined to have been manufactured at the Qingdao facility.
 
 
 
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