heparin


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heparin

(hĕp`ərĭn), anticoagulantanticoagulant
, any of several substances that inhibit blood clot formation (see blood clotting). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other
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 produced by cells in many animals. A polysaccharide, heparin is found in the human body and occurs in greatest concentration in the tissues surrounding the capillaries of the lungs and the liver. The substance, extracted from animal tissues, is used clinically to delay blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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heparin

[′hep·ə·rən]
(biochemistry)
An acid mucopolysaccharide acting as an antithrombin, antithromboplastin, and antiplatelet factor to prolong the clotting time of whole blood; occurs in a variety of tissues, most abundantly in liver.
References in periodicals archive ?
For the 12 months ending 31 October 2017, US sales for the company's Heparin Sodium Injection USP, 1,000 USP/ml, 5,000 USP/ml, 10,000 USP/ml and 20,000 USP/ml were about USD185m, according to IQVIA.
Re-exposure to heparin flush solution 2 months later caused the same anaphylactic symptoms, along with respiratory problems requiring ventilation.
Our earlier studies showed that serum heparin levels in mice increased significantly during starvation.
CZSPL obtained crude heparin from consolidators, which combined smaller lots of crude heparin into larger lots.
Although naturally and physiologically involved in the clotting process, increased levels of thrombin are associated with pathological states and can be controlled by the anti-Xa activity of pharmacological agents such as heparin and LMWH, which are historically delivered subcutaneously.
7 L of heparinised saline (2500 IU/L unfractionated sodium heparin) or with heparin-free saline to assess the effect of heparin priming.
Predictors for heparin resistance in patients undergoing coronary artery bypass grafting.
February 2 Low molecular weight heparin for curative purposes 2 inj / Day
Heparin-induced thrombocytopenia (HIT) is a relatively common complication affecting approximately 5%-30% of patients exposed to heparin.
The crude catheter non patency was 4% (two catheters) in heparin group and 8% (four catheters) in the sodium chloride group.
As the standard protocol practiced at our institution the heparinised saline containing 12500 IU of heparin in 1 liter of 0.
Basic compounds, such as protamine sulfate or hexadimethrine bromide (polybrene), can neutralize heparin, which is an acidic glycosaminoglycan.