A total of 40 cases of hepatorenal syndrome
were enrolled, out them 20 patients received the terlipressin dose (study group) and remaining 20 patients did not receive terlipressin (control group).
Conclusion: T allele located at arginine vasopressin receptor 1a receptor promoter rs113481894 locus may be associated with the pathogenesis of type I hepatorenal syndrome
is one of the dreadful terminal complications encountered in patients with advanced cirrhosis.
Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome
and improves survival in cirrhosis.
Out of 18 cirrhotic patients, 4 patients died of hepatic encephalopathy, while 4 patients died of hepatorenal syndrome
Liver cirrhosis is accompanied by a host of complications, specially the hepatorenal syndrome
, causing retention of sodium and free water, decrease in renal perfusion and GFR (3), thereby leading to edematic, and ascitic conditions.
Therapy Insight: management of hepatorenal syndrome
The major complications of cirrhosis are ascites, gastroesophageal varices-related bleeding, hepatic encephalopathy, hepatorenal syndrome
and hepatocellular carcinoma (HCC).
Although the primary cause of renal failure in hepatorenal syndrome
is intense renal vasospasm leading to renal hypoperfusion, it is thought that toxic tubular damage as a result of the accumulation of bilirubin and bile salts within the tubules may also play a role.
has announced that its partner, Orphan Therapeutics LLC, has completed enrollment in the pivotal Phase 3 clinical research study of terlipressin for the treatment of type 1 hepatorenal syndrome
(HRS), a life-threatening complication of liver cirrhosis characterized by rapidly progressive kidney failure.
KEY WORDS: alcoholic liver disorder; diagnosis; disease complication; treatment method; lifestyle; nutritional deficiency; vitamin therapy; drug therapy; propylthiouracil; colchicines; corticosterone; alternative medical treatment; S-adenosylmethionine; ascites; peritonitis; kidney disorder; esophageal varix; pentoxifylline; hepatorenal syndrome
It also reviews key players involved in the therapeutic development for Hepatorenal Syndrome