hepatomegaly

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hepatomegaly

[‚hep·əd·ō′meg·ə·lē]
(medicine)
Enlargement of the liver.
References in periodicals archive ?
The purpose of this study is to establish the hepatoprotective role of melatonin in MTX induced hepatotoxicity in mice.
Here, we propose a systems approach to model hepatotoxicity that integrates toxicity assays and transcriptomics data with validated genome scale metabolic models (GEMs).
Results: One hundred-fifty-six episodes of hepatotoxicity occurred in 107 patients in 281 KTR, with an incidence of 38%.
Reversibility of nickel induced hepatotoxicity was observed after intramuscular administration of 10 mg/100g body weight of alpha-tocopherol by Tikare et al.
At 3 months followup, there were improvements in ALT levels of both cases and controls as evident from reduction in number of patients who had moderate-to-severe hepatotoxicity (Grade 2 and Grade 3).
7,8) To the best of our knowledge only three cases of hepatotoxicity occurring in HLA B*5701-negative patients with no viral hepatitis co-infection or history of alcohol abuse have been reported; all cases were on a stable NVP-based regimen after switching to ABC from another nucleoside analog.
Since hepatoprotective effect of methanolic extract of pomegranate peel (MEPP) had never been tried on acetaminophen-induced hepatotoxicity, the present study was designed to observe the acetaminophen- induced histological and functional changes in the liver of rat and the effect of MEPP on these changes.
Purpose: This study aimed to investigate the effect of Tan on APAP-induced hepatotoxicity and the underlying mechanisms involved.
On the other hand, activation of PPAR[gamma] inhibited the fibrogenic response to liver injury [16] and protected against drug-induced hepatotoxicity as we recently reported [3, 17, 18].
Based on a Roussel Uclaf Causality Assessment Method overall score of 9 point, our patient had drug-induced hepatotoxicity.
The irony of herbal hepatitis: Ma-Huang-induced hepatotoxicity associated with compound heterozygosity for hereditary hemochromatosis.
The FDA recommendations also reduced the maximum daily dose to 3250 mg from 4000 mg, encouraging manufacturers to reduce the amount of acetaminophen to 325 mg per dose and clarifying warning labels and nomenclature to highlight the potential for severe hepatotoxicity.