Neuropathy

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neuropathy

[nu̇′räp·ə·thē]
(medicine)
Any disease affecting neurons.

Neuropathy

 

a functional weakness of the nervous system accompanied by a decrease in the absolute threshold (also called the stimulus, or sensitivity, threshold); the condition is frequently congenital.

Neuropathy arises as a disturbance in the function of the autonomic nervous system owing to deleterious influences on the fetus as a whole (for example, infection in the pregnant mother, trauma, or poisoning) or on the individual embryonic cells (as occurs when the parents suffer from alcoholism). Family circumstances, upbringing, and illnesses suffered by the infant play a role in the pathogenesis of neuropathy. The symptoms usually emerge in childhood or adolescence. When neuropathy occurs in early childhood, disturbances of sleep and appetite are most characteristic; the infant has difficulty in falling asleep, awakes easily, suckles poorly, and frequently spits up. Later, vomiting occurs, and either diarrhea or constipation develop.

From the preschool years on, increased general excitability and the rapid onset of fatigue and exhaustion are observed, in addition to continued disturbances of sleep and appetite. Children who suffer from neuropathy blush easily in response to irritation. Motor hyperactivity, nervous tics, and stammering are frequent. In adolescence, autonomic-vascular instability becomes more acute, as evidenced by frequently occurring nervous palpitation, abrupt shifts in blood pressure, headaches, dizzy spells, and fainting spells. The prognosis is favorable, with the neuropathic symptoms usually disappearing with age.

REFERENCES

Simson, T. Nevropatii, psikhopatii i reaktivnye sostoianiia mladencheskogo vozrasta. Moscow-Leningrad, 1929.
Sukhareva, G. E. Klinicheskie lektsii po psikhiatrii detskogo vozrasta, vol. 2. Moscow, 1959.

L. M. SHMAONOVA

References in periodicals archive ?
We included 17 axonal neuropathy (AN) patients, 11 vasculitic neuropathy (VN) patients and 12 hereditary neuropathy with liability to pressure palsy (HNPP) who had undergone sural and superficial peroneal nerve biopsy as part of the diagnostic work-up of their neuropathy and whose nerve biopsy specimens were suitable for the immunohistochemical analysis.
A frameshift mutation in the PMP22 gene in hereditary neuropathy with liability to pressure palsies.
PCR-based strategy for the diagnosis of hereditary neuropathy with liability to pressure palsies and Charcot-Marie-Tooth disease type 1A.
Novel PCR-based diagnostic tools for Charcot-Marie-Tooth type 1A and hereditary neuropathy with liability to pressure palsies.
Charcot-Marie-Tooth disease type 1A and hereditary neuropathy with liability to pressure palsies: a Sacl polymorphism in the proximal CMT1A-CMT1A-REP elements may lead to genetic misdiagnosis.
Molecular diagnosis of Charcot-Marie-Tooth IA disease and hereditary neuropathy with liability to pressure palsies by quantifying CMTIA-CMTIA-REP sequences: consequences of recombinations at variant sites on chromosome 17p11.
16, 2014 /PRNewswire/ -- The French biopharmaceutical company Pharnext SAS and the Hereditary Neuropathy Foundation (HNF) announced today an agreement to collaborate on programs to increase the awareness around Charcot-Marie-Tooth (CMT) disease and support the development of a stronger CMT patient and research community.
For more information about Hereditary Neuropathy Foundation, please visit: www.
Allison Moore, Founder & President of the Hereditary Neuropathy Foundation, understands the importance of having one's medical history with them at all times.
FIGURE 28 HEREDITARY NEUROPATHY DRUG MARKET BY REGION, 2010-2017 ($ MILLIONS) 87
TABLE 51 LEADING MANUFACTURERS AND SUPPLIERS OF HEREDITARY NEUROPATHY

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