hereditary spherocytosis


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Related to hereditary spherocytosis: Hereditary elliptocytosis

hereditary spherocytosis

[hə′red·ə‚ter·ē ‚sfer·ō‚sī′tō·səs]
(medicine)
A chronic congenital disorder of the erythrocytopoietic system characterized by a preponderance of spherical erythrocytes, increased osmotic fragility, hemolytic anemia, and splenomegaly.
References in periodicals archive ?
Red cell life span after splenectomy in hereditary spherocytosis.
Patients with thalassemia major and hereditary spherocytosis were vaccinated at diagnosis with hepatitis B vaccine (3 injections at a dose of 10 [micro]g) if they were seronegative.
Iolascon A, Faienza MF, Moretti A, et al: UGT1 promoter polymorphism accounts for increased neonatal appearance of hereditary spherocytosis.
It may be helpful in determining whether impaired glucuronidation contributes to clinical hyperbilirubinemia in subjects with abnormalities in bilirubin metabolism, as in subjects with heterozygous [beta]-thalassemia (17), glucose-6-phosphate dehydrogenase deficiency (18), neonatal icterus associated with glucose-6-phosphate dehydrogenase deficiency (19), or hereditary spherocytosis (20).
Splenic artery embolization was first described in the 1970s and has since been used in different clinical settings, including traumatic spleen rupture, portal hypertension-related ascites, immune throm-bocytopenic purpura, hemoglobinopathies, and hereditary spherocytosis (1-5).
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