heterodimer


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Related to heterodimer: Homodimer, Heterodimerize

heterodimer

[‚hed·ə·rō′dī·mər]
(biochemistry)
A protein made of paired polypeptides that differ in their amino acid sequences.
References in periodicals archive ?
A new test to measure total HER2 as well as HER2 homodimers and heterodimers is also available as a predictor for efficacy of anti-HER2 therapies.
Conducting additional studies in both metastatic and adjuvant breast cancer using an expanded menu of VeraTag assays (which may include: HER2 total protein and homodimer, HER1 total protein and homodimer, HER3 total protein, HER1:2 and HER2:3 heterodimers, HER3-PI3K, and p95) to investigate why patients fail targeted therapies, and thus to understand how targeted inhibitors of the EGFR-family of receptors might be combined for better patient outcomes.
Data on the HER2:HER3 heterodimer assay and the HER3:PI3K complex assay will be presented at the AACR "Targeting the PI3-Kinase Pathway in Cancer" meeting in Cambridge, MA in November.
A third poster presentation (Poster #4040), entitled "Proximity-based assays for the detection of activated HER3, HER2/HER3 heterodimers and HER3/PI3K complexes in formalin-fixed, paraffin-embedded cell line controls and tumors" will be presented by Monogram scientists in Exhibit Hall B on Saturday December 13 from 7:00-9:00 am.
14,15) The HIF-1 heterodimer, a basic helix-loop-helix-Per-Arnt-Sim transcription factor, can then bind to gene regulatory sequences termed hypoxia-response elements of several target genes downstream from HIF-1[alpha], including the genes encoding vascular endothelial growth factor (VEGF), the glucose transporter (GLUT1), platelet-derived growth factor (PDGF), transforming growth factor a, and erythropoietin.
In the presence of TCDD, it forms an active heterodimer with the aromatic hydrocarbon nuclear translocator (ARNT/HIF-1[beta]) and induces (or suppresses) the transcription of numerous genes, including P4501A1 (CYP1A1) (Whitlock 1999).
Evidence for a primary association of celiac disease to a particular HLA-DG alpha/beta heterodimer.
This lack of parallelism is often encountered for the heterodimer human chorionic gonadotropin (hCG), of which many molecular forms exist.
PPAR acts as a heterodimer with retinoid X Receptor (RXR) to regulate transcription, and once activated, PPAR regulates the transcription of genes containing specific peroxisome proliferator response elements within DNA (Corton et al.
The presence of 3 bands is most likely due to heteroduplex band formation (2 homodimer bands and a heterodimer between 2 alleles).
These assays provide quantitative measurements of the HER2:HER3 heterodimer, and its associated downstream HER3:PI3K complex.