heterophile antibody


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Related to heterophile antibody: heterophile antigen

heterophile antibody

[′hed·ə·rə‚fīl ′an·ti·bäd·ē]
(immunology)
Substance that will react with heterophile antigen; found in the serum of patients with infectious mononucleosis.
References in periodicals archive ?
The diagnosis of infectious mononucleosis was based on the patient's history, physical examination, laboratory findings, serological detection, and heterophile antibody test.
The study compared antibody levels in 139 serum specimens from patients with recent primary EBV infections (confirmed by both a positive heterophile antibody test and an EBV antibody pattern compatible with recent infection) and in 40 specimens from healthy normal controls.
Finally, once the mononucleosis has resolved, heterophile antibody and IgM VCA will both be negative, while IgG VCA and EBNA will be positive.
To avoid this, serum specimens should be mixed with staphylococcal protein A to adsorb the rheumatoid factor--an unnecessary complication with the existence of the heterophile antibody test.
3) He also had the typical clinical picture, hematologic changes, and serologic response of infectious mononucleosis, ie, a young adult with sore throat, malaise, fatigue, headache, pharyngitis, abnormal liver function tests, a relative and absolute lymphocytosis with an elevated percentage of atypical lymphocytes, and a positive heterophile antibody test.
A rare individual can have persistent heterophile antibody years after recovery.
Many physicians would look at the negative heterophile antibody result in conjunction with a complete blood count report and reassess their differential diagnosis.
rheumatoid factor, rapid plasma reagin, ASO, hCG, heterophile antibody, etc.
The assumption was made that a heterophile antibody test was initially requested by the patient's physician in response to presenting clinical signs and symptoms suggestive of an infectious mononucleosis-type illness.
To determine if the discrepant results were caused by heterophile antibody interference, we added 500 [micro]L of patient sample (n = 11) to a Scantibodies Laboratory Heterophilic Blocking Tube (HBT) and incubated the tube for 1 h before measuring 25-hydroxyvitamin D on the LIAISON instrument.
The classic diagnostic approach is to get a CBC and heterophile antibody test such as a Monospot.
Protein regions within the cTnI molecule that are susceptible to the modifications noted above--as well as the variable nature of epitope-dependent heparin (4), heterophile antibody (5), and autoantibody (6) binding--are likely to exhibit variable immunoreactivity and even loss of reactivity in some cases.