heterozygote advantage


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heterozygote advantage

[‚hed·ə·rō¦zī‚gōt ad′van·tij]
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With teacher guidance, students will become familiar with many genetics concepts: probability, dominant and recessive traits, sex-linked traits, penetrance, dosage compensation, Barr bodies, pleiotropy, founder effect, aneuploidies, environmental interactions, allele polymorphisms, heterozygote advantage, and the outcomes and ethics of genetic screening.
Yet, frequencies of these deleterious alleles are much higher in the Ashkenazi as compared to the general European population, raising the possibility of a selective heterozygote advantage for the carrier.
The views that there is a' heterozygote advantage ', but that there are also specific risks to specific abilities in the homozygotes and heterozygotes, makes it potentially difficult to invalidate the theory.
Heterozygote advantage for HLA class-II type in hepatitis B virus infection.
Theoretical considerations indicate that heterozygote advantage at marker loci can be caused by deleterious genes that are recessive or partially recessive and linked in repulsion, by true overdominant gene action, or by linkage to either case (Falconer, 1989).
Simulation studies, however, suggest that variability might not be lost as rapidly as indicated by Wright's model (Lesica and Allendorf 1992); selection for heterozygotes, whether heterozygote advantage results from overdominance or inbreeding or some other cause, could slow the loss of alleles.
Taking account of the further development of her theory (Annett & Manning, 1989, 1990a), there is a human balanced polymorphism for laterality and ability with heterozygote advantage.
Researchers have suggested that the mutant cftr gene persists so widely because of a heterozygote advantage.
l] is the heterozygote advantage (overdominance) at locus l (Log[1 + [H.
This overlooks the fact that, in a two-allele system, such equality is only possible with complete dominance; if there are three distinct phenoptypes which are subject to selection, it is well known that heterozygote advantage or disadvantage is required for equilibrium.
She has used these data to support her genetic model of handedness, and to argue for a balanced polymorphism with a heterozygote advantage (Annett, 1985).
It was therefore clear that there could be a heterozygote advantage, or why did a gene to promote left cerebral speech evolve and then not spread throughout the population?