The preparations were preincubated with either atropine or hexamethonium
and then exposed to [alpha]-hederin.
Similar to this finding, it has been showed that also the BP increase can be attenuated by pharmacological blockade of the autonomic nervous system with hexamethonium
, indicating that it is mediated by the SNS rather than by mechanical factors related to changes in intrathoracic pressure.
Others are contemporary cases, including two high-profile examples involving the death of research subjects which led to at least temporary closure of research programs at the sponsoring universities--the death of Jesse Gelsinger in a gene therapy study, and the death of a healthy volunteer exposed to inhaled hexamethonium
in a lung physiology study.
He enlisted healthy volunteers to inhale a chemical irritant, hexamethonium
86) Further, it was claimed that the IRB had "failed to obtain sufficient information regarding the source, purity, quality, and method of preparation and delivery of the hexamethonium
used in the research.
According to Varmus: "Think about hexamethonium
, the drug that killed a student at Johns Hopkins.
Some of those volunteers would also be given hexamethonium
, a so-called ganglionic blocker that would prevent signals from returning to the lungs--and, if the theory was right, stop the airways from reopening.
pretreatment, suggesting that it may result from vasodilatory action of EOAZ directly upon vascular smooth muscle rather than withdrawal of sympathetic tone (Lahlou et al.
Several agents are classically associated with drug-induced bronchiolitis (penicillamine, hexamethonium
, busulphan), whereas others have bronchiolitis listed as an idiosyncratic reaction.
These were inhibited by atropine, hexamethonium
and ondansetron suggesting that cholinergic and 5-H[T.
In the first set of experiments, the right vagus nerve was stimulated in 5 cats and the effects on heart rate were recorded: 1) before and after blockade of the PA ganglion with hexamethonium
; and 2) after allowing time for the effects of hexamethonium
to wear off.
MCAF was more potent than ACPF in contracting the colon, Hexamethonium