hexobarbital


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hexobarbital

[¦hek·sə′bär·bə·tȯl]
(pharmacology)
C12H16N2O3 A sedative and hypnotic of short duration of action; used also, as the sodium derivative, to induce surgical anesthesia.
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Like other barbiturates decreased duration of hexobarbital sleeping time is a well known indicator of impaired drug metabolism.
The volatile fraction of the petroleum ether extract potentiated the sedative activity with pentobarbital, hexobarbital, and ethanol in mice (Dandiya and Cullumbine 1959).
Examples of some clinical applications for cyclodextrins in HPLC include methods reported for chlorpheniramine (158), citalopram, desmethylcitalopram, and didesmethylcitalopram (159), hexobarbital (158), the M1 and M2 metabolites of moguisteine (160), and propranolol (161).
In brief, male Wistar rats weighting 150-180 g were anesthetized with hexobarbital (40 mg/kg i.
Stereoselective disposition of hexobarbital and its metabolites: relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects.
2002), and prolongation of sleeping time induced by the administration of hexobarbital (Sugaya et al.