High-grade squamous intraepithelial lesion
was the second most-common, abnormal Pap test result in 917 of 3649 patients (25.
Abbreviations: AGC, atypical glandular cells; AIS, adenocarcinoma in situ; ASC-H, atypical squamous cells, a highgrade squamous intraepithelial lesion cannot be ruled out; ASC-US, atypical squamous cells; HSIL, high-grade squamous intraepithelial lesion
; LSIL, low-grade squamous intraepithelial lesion; LSIL-H, low-grade squamous intraepithelial lesion, a high-grade squamous intraepithelial lesion
cannot be ruled out; SCCA, squamous cell carcinoma.
Perhaps a more fruitful way to detect more false-negative Pap findings in retrospective rescreening is to also include cervical biopsy specimens diagnostic of a high-grade squamous intraepithelial lesion
or worse to trigger review.
The cumulative risk of high-grade squamous intraepithelial lesions
was 5% among HIV-positive women and 3% among seronegative women.
A 1999 Kaiser Permanente study of 137 women with cytologic atypical glandular cells (AGC) found that HPV DNA testing identified 94% of those with high-grade squamous intraepithelial lesions
(HSIL) and 100% of those with endocervical adenocarcinoma in situ (Hum.
Food and Drug Administration (FDA) has approved a Premarket Approval (PMA) Supplement allowing inclusion of data describing the detection of High-Grade Squamous Intraepithelial Lesions
(HSIL) with the ThinPrep(R) Pap Test(TM).
Low-grade squamous intraepithelial lesions (LSIL) were seen in 57% atypical squamous cells of undetermined significance (ASCUS) in 30%, high-grade squamous intraepithelial lesions
(HSIL) in 7%, and atypical squamous cells in which HSIL cannot be excluded (ASC-H) in 5.
focused on the effectiveness of the AutoPap Primary Screening System in detecting high-grade squamous intraepithelial lesions
and cancer (HSIL+).
Progression of anal high-grade squamous intraepithelial lesions
to invasive anal cancer among HIV-infected men who have sex with men.
Details of all patients with atypical squamous cells of undetermined significance (ASCUS), human papillomavirus (HPV), low-grade squamous intraepithelial lesions (LSILs), high-grade squamous intraepithelial lesions
(HSILs), atypical glandular cells of undetermined significance (AGUS) and suspected cervical carcinoma (Ca) were extracted.
With optimal testing systems, HPV DNA can be identified in nearly all specimens of invasive cervical cancer and in the vast majority (>95%) of the immediate cervical cancer precursors, namely high-grade squamous intraepithelial lesions
(HSILs)-also known as cervical intraepithelial neoplasia 3 (CIN 3) or carcinoma in situ (6-8).
High-grade lesions are rare in teenagers, occurring in 3 cases per 1,000 15-to 19-year-olds, and they take years after sexual debut for high-grade squamous intraepithelial lesions
to develop and 5 years for invasive cancers to emerge," he said at a conference on contraceptive technology sponsored by Contemporary Forums.