Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal
cultures exposed to anoxia/aglycemia or to excitotoxins.
They then measured the rates of hippocampal
and cortical atrophy and tried to decide if the shrinkage was driven by TDP-43, tau, or both.
Here, we provide evidence of a causal relationship between PCB-95--induced dendritic growth and RyR activation in hippocampal
Patients in the donepezil group exhibited a 45% lower rate of hippocampal
atrophy than those in the placebo group after 1 year (-1.
Now, Carnegie Mellon University scientists have determined that learning detailed navigation information causes the hippocampal
Pharmacological data indicate that TEN could promote proliferation and differentiation in hippocampal
neural stem cell (Chen et al.
Mingyan Wang and team from Nanjing University of Chinese Medicine for the first time, used cytobiological and molecular biology methods to investigate the molecular mechanisms underlying the neuroprotective effects of 5-hydroxymethylfurfural on rat hippocampal
neurons injured by oxidative stress.
This effect was accompanied by a significant increase in hippocampal
oxidative stress and DNA damage.
A total of 38% had brain imaging abnormalities, including evidence of silent infarcts and hippocampal
atrophy, and 18% had ischemic lesions.
Earlier investigations in rodents had indicated that specific patterns of hippocampal
activity in animals learning spatial tasks reappear during slow-wave sleep, a stage of deep sleep, but not during rapid eye movement (REM) sleep.
After correcting for gender and for physiological maturity, they found that kids with more severe PTSD symptoms and higher bedtime cortisol levels (another marker of stress) at the start of the study were more likely to have reductions in their hippocampal
volumes at the end of the study than their less-affected, but still traumatized peers.
Experience alters hippocampal
activity and anatomy.