Hippuric Acid

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Related to Hippurate: hippurate hydrolysis

hippuric acid

[hi′pyu̇r·ik ′as·əd]
(organic chemistry)
C6H5CONHCH2·COOH Colorless crystals melting at 188°C; soluble in hot water, alcohol, and ether; used in medicine and as a chemical intermediate.

Hippuric Acid


benzoylglycine, C6H5CONHCH2COOH, a compound consisting of benzoic acid and glycine groups; colorless, crystalline; melting point, 187.5° C.

Hippuric acid is formed in most animals and in man, primarily in the liver, and passes out in the urine. The biological significance of hippuric acid synthesis in the body is in the binding of benzoic acid, which is liberated during the destruction of the aromatic compounds that are a part of the makeup of plant tissues. In clinical practice the liver’s detoxication ability is measured by a test for hippuric acid synthesis (Quick’s test).

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Meanwhile, among the 10 potential biomarkers associated with blood stasis in rat urine, changes of 8 biomarkers including N-acetyl glycoprotein, succinate, 2-oxoglutarate, citrate, glycine, sarcosine, phenylacetylglycine and hippurate were significantly reduced by puerarin (Fig.
Changes in hippurate and aromatic metabolites are closely correlated to the activities of gut microflora (Phipps et al.
Qualitative phase analysis of the samples showed presence of organic compounds like GB- Naphthylbismuth dioxide (1), Sodium hippurate (2), Sodium-GA-naphthylamine-4-sulfonate tetrahydrate (3), Potassium phenoxide (4), Bismuth salicylate (5), Cadmium salicylate hydrate (6), Barium phenolsulfonate (7) the relevant codes specified in brackets shown in (Table 2).
2011; Walther 1988) Premature birth: high blood Markers that vary with pressure (males) and diabetes gestational age: hippurate, (Johansson et al.
A variable behavior was demonstrated in the production of nitrate reductase, urease, and reduction of hippurate.
10) Pharmacological management of ammonia removal includes sodium phenylacetate, sodium benzoate, and sodium phenylbutyrate, which act in combination with glutamine or glycine and convert ammonia to either phenylacetylglutamine or hippurate that are easily excreted by kidneys.
The two agents that are best supported in the literature for chronic low-dose prophylaxis are nitrofurantoin and methenamine hippurate.
16]) and mean 24-hour urinary excretion of alanine (direct) and hippurate (inverse), reflecting diet and gut microbial activities, were also associated with blood pressure of these individuals.
The tests used included oxidase tests, hippurate hydrolysis, nitrate reduction, hydrogen sulphide production (in triple sugar iron agar), and susceptibility to cephalothin and nalidixic acid.
However it was unable to utilize sucrose, raffinose, adonitol, methyl A-D mannoside, inositol, xylitol, isobutyrate, methyl A-D glucopyranoside, salicin, D-melizitose and hippurate.
The efficacy of methenamine hippurate has been demonstrated in some studies but not in others.