histiocyte


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Related to histiocyte: Langerhans cell

histiocyte

[′his·tē·ə‚sīt]
(histology)
References in periodicals archive ?
Microscopically, the lesion is characterized by dense aggregates of large mononuclear histiocytes (the 'von Hansemann' cells) admixed with intracellular and extracellular calcied granular inclusions known as Michaelis-Gutmann bodies and lymphoplasmacytic inltrate.
Emperipolesis related to RDD refers to the presence of histiocytes containing intact lymphocytes within their cytoplasm.
7) Erdheim-Chester disease shares some clinical features with LCH, including involvement of bone and multiple other sites, but tends to occur at an older age and is histologically characterized by foamy histiocytes without expression of CD1a or S100.
A repeated bone marrow biopsy presented 100% cellularity, marrow elements mostly composed of histiocytes and markedly decreased marrow elements.
Morphologically, the tumour pattern, as seen in other subtypes, is composed of a mixture of fibroblasts, histiocytes and osteoclast-type giant cells in relatively changing amounts.
The patient underwent a bone marrow biopsy and aspiration which showed that her cellular marrow was infiltrated with abnormal histiocytes plus multiple granuloma consistent with hemophagocytosis (Figures 1 and 2).
During our patient's hospitalization, we were able to investigate 6/8 diagnostic criteria for HLH proposed by the Histiocyte Society (3).
In 1991, the first international randomized chemotherapy trial LCH-I for patients with multisystem LCH was initiated by the Histiocyte Society.
2,4) These metallic fragments become engulfed by histiocytes that then release inflammatory mediators, which, in turn, activate osteoclasts, resulting in bone resorption.
In both forms of the disease there is excessive activation of the macrophages and histiocytes producing haemophagocytosis in bone marrow and reticuloendothelial system.
The histiocyte count is sometimes increased in AA just like plasma cells, but this is a relative increase and is not associated with hemophagocytosis.
FIGURE 4: Oil immersion view of Bone marrow aspirate smear showing large histiocyte with central nucleus and foamy cytoplasm (Leishman stain, X1000).