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histocompatibility |
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histocompatibility: see transplantation, medical transplantation, medical, surgical procedure by which a tissue or organ is removed and replaced by a corresponding part, either from another part of the body or from another individual. ..... Click the link for more information. . histocompatibility [¦hi·stō·kəm′pad·ə′bil·əd·ē] (immunology) The capacity to accept or reject a tissue graft. Histocompatibility A term used to describe the genes that influence acceptance or rejection of grafts. When grafts of tissue are exchanged between genetically dissimilar individuals, profound immunological rejection generally takes place. In contrast, grafts between genetically similar individuals, such as identical twins, are normally tolerated; they are histocompatible. Most known examples of histocompatibility (or H) genes encode polymorphic (that is, tending to differ between individuals) cell-surface proteins. The major histocompatibility complex (MHC) contains a set of histocompatibility genes, termed major because mismatching at these genes invokes rapid rejection. The main function of MHC genes involves distinguishing self from nonself in the immune system, as part of preventing the spread of infectious disease. The body employs special mechanisms to avoid rejection of the fetus, which is effectively an allograft, that is, a graft from a donor to a genetically dissimilar recipient of the same species; in this case, the mechanisms include a diminution of MHC gene expression. The MHC contains a spectrum of genes, many of which influence processing and presentation of antigens to the immune system. In mice, the MHC is designated the H-2 complex; in humans, it is referred to as the HLA complex (for human leukocyte A system). Mice and other mammals seem to have a similar arrangement of genes in their MHCs. See Antigen, Cellular immunology, Mendelism, Transplantation biology How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| These class II major histocompatibility complex (MHC) proteins present the peptides to immune cells called helper T cells, which coordinate the body's response. The goal of the HEP is to locate, identify, and catalog methylation variable positions within the human genome, The partners have conducted a pilot study of the methylation patterns within the major histocompatibility complex, a region of chromosome 6 that is associated with more diseases than any other region of the human genome. The CD4+ T helper cells are primarily responsible for helping other immune cells through direct cell-cell interactions or by secreting cytokines after recognizing viral peptides bound to major histocompatibility complex (MHC) class II molecules. |
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