homeobox


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.

homeobox

[′hō·mē·ə‚bäks]
(cell and molecular biology)
A highly conserved sequence of deoxyribonucleic acid (DNA) that occurs in the coding region of development-controlling regulatory genes and codes for a protein domain that is similar in structure to certain DNA-binding proteins and is thought to be involved in the control of gene expression during morphogenesis and development.
Mentioned in ?
References in periodicals archive ?
En cuanto al gen Homeobox Arx, se dice que tiene una accion indirecta en la diferenciacion de las celulas intersticiales, ya que tiene una expresion mas elevada en las celulas mioides.
Hasta la fecha, los estudios de asociacion genetica han sugerido que los genes apoptoticos, homeobox A y D (HOXA y HOXD) y de contraccion muscular contribuyen a la responsabilidad genetica subyacente.
17 Other proteins include, POU class 5 homeobox 1 (OCT4), baculoviral IAP repeat containing 5 (BIRC5), cyclin D1 (CCND1), ATP binding cassette subfamily G member 2 (BCRP), SRY-box 2 (Sox2), Glutathione S-transferases (GST), NCK adaptor protein 1 (NCK1), human leukocyte antigen DQ (HLA-DQ), miR-106b, c-Myc, Ki67 and selective internal radiation therapy (SIRT).
These included Diencephalon/mesencephalon homeobox protein 1 -B, Homeobox vent 1, Kruppel-like factor 7.
sup][3] This gene belongs to a superfamily of POU domain transcription factors (transcription factor 4 of the POU domain, Class III), which encodes transcription factor with bipartite DNA-binding domains, a 75-amino acid POU-specific domain that is linked by 17 amino acids to a 63-amino acid homeobox domain.
This event may partially be regulated by the HHEX homeobox genes that regulate the proliferation of endoderm of the anterior intestine and the activation of the epithelium with respect to the cardiac mesoderm that produces FGF during development (23).
Homeobox protein (NOBOX)--the newborn ovary homeobox gene is an oocyte--is a specific expressed gene with an essential role in folliculogenesis and so one of the candidate genes for PPOI(28).
3] Defect in expression of homeobox and paired-box genes (Pax 1 and Pax 9), which control cell proliferation during early sclerotome development results in boundary shifts at the transitional areas of the vertebral column leading to lumbarisation and sacralisation.
The most important genes clustering CTCs in the subgroups were cadherin 2 (CDH2), collagen type I alpha 2 chain (COL1A2), collagen type V alpha 2 chain (COL5A2), fibronectin 1 (FN1), microtubule associated protein 1B (MAP1B), matrix metallopeptidase 3 (MMP3), SRY-box 10 (S0X10), secreted phosphoprotein 1 (SPP1), zinc finger E-box binding homeobox 1 (ZEB1), and zinc finger E-box binding homeobox 2 (ZEB2; Fig.
In the past, researches have highlighted the protective effect of smoking by associating smoking with increased progesterone receptors (PGR) and homeobox A10 (HOXA10) expression in human endometrium and endometrial cells.
Homeobox genes are involved in body plan formation and in the regulation of many developmental processes in bilateria.