homeobox

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Related to homeobox gene: Hox gene

homeobox

[′hō·mē·ə‚bäks]
(cell and molecular biology)
A highly conserved sequence of deoxyribonucleic acid (DNA) that occurs in the coding region of development-controlling regulatory genes and codes for a protein domain that is similar in structure to certain DNA-binding proteins and is thought to be involved in the control of gene expression during morphogenesis and development.
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We previously observed that a 4-day treatment with TCDD after the completion of EB formation deregulated the expression of > 50 homeobox genes, many by as much as 50- to 100-fold above or below the control (Wang et al.
The homeobox gene BREVIPEDICELLUS is a key regulator of inflorescence architecture in Arabidopsis.
Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry.
Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification.
An estrogen receptor antagonist blocked these effects, indicating that they were induced by the estrogenic activity of Gen, Oviducts of adults treated neonatally with Gen had abnormal morphology and were stably "posteriorized," as indicated by altered Hoxa gene patterning during the time of treatment and dramatic, permanent up-regulation of homeobox genes (e.
Other researchers later discovered homeobox genes with identical DNA sequences in mice, humans and other vertebrates.
For example, homeobox genes control the differentiation fates of tissues and organs by influencing the expression of multiple other genes that act in concert with one another to direct complex cellular behaviors.
Members of the Antennapedia class of homeobox genes, known as Hox genes, are believed to be pivotal in regulating vertebrate craniofacial development and controlling morphogenesis and the growth of the proximal-distal axis.
Although researchers know that alcohol can affect the expression of some genes, it is uncertain whether these include homeobox genes.
Hake and others have now used the Knotted homeobox as a probe to identify more than a dozen other homeobox genes in corn, plus some in tomatoes, barley, peas, and rice.
Paleobiologists bring many analytical tools to bear in interpreting the fossil record and the book introduces the latest techniques, from multivariate investigations of biogeography and biostratigraphy to engineering analysis of dinosaur skulls, and from homeobox genes to cladistics.