homocysteine


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Related to homocysteine: homocysteine test, Methylmalonic acid, C reactive protein

homocysteine

[¦hä·mə′sis·tēn]
(biochemistry)
C4H9O2NS An amino acid formed in animals by demethylation of methionine.
References in periodicals archive ?
The debate about homocysteine and atherosclerosis dates back to 1968.
We estimated the association between recent exposure to Pb, measured by blood Pb concentration, and concurrent homocysteine concentration.
On the other hand it seems that conversion pattern of methionine to homocysteine is similar in mammals and birds [7].
Inherited hyperhomocysteinemia occurs in mild (<50 [micro]mol/L) or severe (>50 [micro]mol/L) forms, based on plasma total homocysteine concentrations.
They were also tested to see if they had raised levels of homocysteine.
Serum total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, creatinine, vitamin B12, folic acid, thyroid stimulating hormone, glycolized hemoglobin, high sensitivity C-reactive protein, erythrocyte sedimentation rate, complete blood count, microalbuminuria, and homocysteine levels were measured.
The adjusted risk of lung cancer was 83% greater among those with a plasma homocysteine level in the highest quintile, with a median level of 15.
The authors wrote in the Journal of the American Medical Association: "Many studies suggest that relative elevation of homocysteine is characteristic of Alzheimer's disease and laboratory research implicates homocysteine in neurodegenerative mechanisms.
Researchers analyzed homocysteine, folate, cholesterol (total, LDL, and HDL), and thrombin-antithrombin complexes and blindly assessed fixed and stained placentas for histologic evidence of infarction and decidual vasculopathy.
Homocysteine has long been suspected as being linked to the atherosclerotic process, which in turn is well known to be implicated in cardiovascular disease.
Rassoul et al (3) in this issue have studied plasma homocysteine level and 677 C[right arrow]T polymorphism in MTHFR gene in patients with coronary artery disease (CAD) and concluded that the serum homocysteine level was associated with severity of CAD, but MTHFR polymorphism did not affect the severity of CAD (3).