homodimer


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Related to homodimer: Heterodimer

homodimer

[‚hō·mō′dī·mər]
(biochemistry)
A protein made of paired identical polypeptides.
References in periodicals archive ?
Analysis of HER2 status by HERmark in approximately 900 patient samples from the FINHER study of Herceptin in the adjuvant setting to assess the relationship of HER2 protein and HER2:HER2 homodimer measurements with clinical outcomes.
The VEGF is a homodimer that comprises 2 polypeptide chains and has a molecular mass of approximately 45 kDa; the single stranded form has a molecular weight of about 23 kDa under denaturing conditions.
We believe the HERmark Assay measures HER2 total protein and homodimer levels very accurately and will help physicians to make treatment decisions with high confidence.
The transcriptional regulation of individual subunits influences the range of GST homodimers and heterodimers formed.
The oral presentation, entitled "Total HER2 and HER2 Homodimer Levels Predict Response to trastuzumab," discussed the findings of a study that investigated the HERmark assay's ability to identify and discriminate among patients with metastatic breast cancer who experienced different degrees of response to trastuzumab.
It has been reported that EL forms a head-to-tail dimer in the human plasma, and the homodimer formation is essential for the maintenance of EL activity (36), as is the case with LPL and HTGL.
13-15) In vitro experiments showed a minimal mtDNA replisome of a heterotrimeric DNA polymerase, which consists of a catalytic subunit (pol [gamma]A) and a homodimer of the accessory subunit (pol [gamma]B), a helicase (Twinkle, encoded by PEO1 [C10ORF2]) and a mitochondrial single-stranded DNA-binding protein (mtSSB).
HERmark(TM), our recently launched breast cancer assay, is bringing new options to breast cancer patients with quantitative measurements of HER2 total protein and HER2:HER2 homodimer.
In the first of these studies, it was demonstrated that within a population of patients that were stringently selected by FISH testing, the HERmark assay was able to measure a gradient of HER2 expression and HER2 homodimer levels that was significantly correlated with time-to-progression and overall survival on Herceptin.
Cell viability and number of human osteoblast CRL-11372 were determined after 3, 6, 11, and 24 hr of incubation by ethidium homodimer and calcein AM staining.
The sensor protein, VirA, of the bacterium is a homodimer that directly detects small phenolic compounds released by wounded cells in the callus exudate, resulting in autophosphorylation of the VirA protein of the constitutively expressed virA gene in the bacterium (B[acute{e}]langer et al.
Besides the lack of the hinge region, some of Genmab's monovalent UniBody([R]) molecules differ only in a few amino acids compared to the native homodimer IgG4 molecules, and the challenge was to create affinity ligands targeting those regions.