homologous recombination


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homologous recombination

[hə¦mäl·ə·gə ‚re·käm·bə′nā·shən]
(genetics)
Deoxyribonucleic acid exchange between identical chromosome regions on homologous chromosomes that occurs naturally during meiosis.
References in periodicals archive ?
p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.
Single nucleotide polymorphisms in the homologous recombination repair genes and breast cancer risk in Polish women.
Characterization of the nonallelic homologous recombination hotspot PRS3 associated with type-3 NF1 deletions.
BRCA2 plays an important role in the regulating of DSBs repair by homologous recombination, a pathway which is dependent upon the recombinase function of Rad51 (Moynahan et al.
bovis BCG Pasteur strain 1173P2 was used as a source of DNA and as the parent strain for deletion of the dppd gene (GenBank accession number NC_008769, locus_tag BCG_0092) by homologous recombination.
AZFc deletions are generated by intrachromosomal homologous recombination, involving elimination of one repetitive sequence at the expense of another, resulting in random appearance of de novo AZF micro-deletions in men.
Homologous recombination and prostate cancer: a model for novel DNA repair targets and therapies.
For now, scientists have used a gene targetting method to delete the gene, one that is not likely to see the light of human trials as it involves homologous recombination at the embryonic stage.
Chen said the FANCI-FANCD2 pathway also is associated with the BRCA1 and BRCA2 pathways, which are involved in homologous recombination repair.
Isodicentric Y chromosomes and sex disorders as byproducts of homologous recombination that maintains palindromes.
In the book researchers explore recent developments in three primary areas: quantitative genetic methods for analysis of homologous recombination and chromosome pairing, development of direct physical assays for DNA intermediates and products of recombination, and cytological techniques for characterizing chromosome behaviors and the patters with which specific proteins associate with meiotic chromosomes.
They found that 2,4-D had a significant effect on the frequency of homologous recombination.