homologous recombination


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homologous recombination

[hə¦mäl·ə·gə ‚re·käm·bə′nā·shən]
(genetics)
Deoxyribonucleic acid exchange between identical chromosome regions on homologous chromosomes that occurs naturally during meiosis.
References in periodicals archive ?
A novel third type of recurrent NF1 microdeletion mediated by nonallelic homologous recombination between LRRC37B-containing low-copy repeats in 17q11.
Homologous recombination and prostate cancer: a model for novel DNA repair targets and therapies.
The agreement resolves a dispute between the two companies related to the interpretation of a license agreement entered into by and between Cellectis and Regeneron in December 2003 pursuant to which Regeneron licensed certain patents and patent applications relating to a process for the specific replacement of a copy of a gene in the receiver genome by homologous recombination.
Two different bu related mechanisms are used in plants for the repair of genomic double-strand breaks by homologous recombination.
DELETION AND EPITOPE-TAGGING OF CELL CYCLE GENES USING UNCLONED PCR FUSION PRODUCTS AND HOMOLOGOUS RECOMBINATION IN ASPERGILLUS NIDULANS
In 1989, the two lines of work came together with the first reports of homologous recombination in embryonic stem cells being used to generate "knockout" mice.
Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombination such that a mature mRNA transcript produced from a genomic region of the genome comprising the genomic exon does not contain the modification are provided.
In addition, the region is rich in repetitive DNA with several Alu repeats which could facilitate homologous recombination with loci throughout the genome.
insertional, site-specific, conditional knockout vectors or systems); 2) development and/or use of techniques supporting more efficient targeting of induced local lesions in genomes (TILLING); 3) development and/or use of technologies for gene inactivation and for gene expression manipulation including, but not limited to, morpholino oligonucleotides, new types of antisense technology, techniques for homologous recombination, techniques for gene trapping, and strategies for directing gene misexpression, or other transgenic methodologies; 4) development of high throughput small molecule screens; 5) development of new genetic or genomic resources that are of high priority for the Xenopus community; 6) development and/or application of novel screens for mutants.
Even though a potentially desirable end product is created, the multiple transformations (gene stacking) are liable to create chromosome instability leading to translocations, duplications and deletions through homologous recombination during germ cell formation and in somatic tissues (mitotic recombination).
The RecFOR pathway of homologous recombination (HR) repairs daughter strand gaps (DSGs) formed when DNA adducts are not repaired by NER before replication.