homovanillic acid


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homovanillic acid

[¦hä·mə·və¦nil·ik ′as·əd]
(biochemistry)
HOC6H3(OCH3)CH2CO2H A major metabolite of 3-O-methyl dopa; used in enzyme determination. Abbreviated HVA.
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More interesting, however, was the result that only 3,4-DHT, but not the diphenols 3,4-DHAA and homovanillic acid, was effective in protecting hepatocytes against lipid peroxidation induced by t-BHP.
Determination of homovanillic acid in urine by stable isotope dilution and electrospray tandem mass spectrometry.
Among these were hippuric acid, homovanillic acid, uracil, 5-fluorouracil, and tryptophan.
Our laboratory recently described LC-MS/MS methods for total homocysteine (16), methylmalonic acid (17), and homovanillic acid (18) as well as for glycosylated transferrin (19), which are currently being used in the clinical laboratory.
The neurotransmitter metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy4-hydroxyphenylglycol (MHPG) in CSF and 5-HIAA, HVA, and vanillylmandelic acid (VMA) in urine were measured with HPLC and electrochemical detection, and the metabolites 3-o-methyldopa and L-dopa in CSF and dopamine, epinephrine, and norepinephrine in urine were measured with HPLC and fluorometric detection.
The ASTED system can easily be adapted to run urinary catecholamines, the organic acids vanillylmandelic acid, 5-hydroxyindoleacetic acid, and homovanillic acid, the methylated catecholamine derivatives, and serotonin (13).
We here present a method that permits injection of an unprocessed urine sample and the simultaneous measurement of E, NE, dopamine (DA), metanephrine (M), normetanephrine (NM), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA), as well as serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA).
It arises from cells of the sympathetic nervous system and has the characteristic of secreting dopamine (DA) [4] and its chief metabolite, homovanillic acid (HVA), in excess (3-5).
The propitious production of a single monoclonal antibody to homovanillic acid (HVA) [1] with suitable specificity might be applicable in routine use as part of a screening procedure for neuroblastoma, but perhaps the authors should also have noted that testing for increased HVA alone is insufficient for biochemical diagnosis of all neuroblastomas [5].
The plasma concentrations of dopamine (DA) metabolites, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), may be used as a predictor of DA turnover [11].
Vanillylmandelic acid (VMA) and homovanillic acid (HVA) correspond to the two major urinary metabolites of both epinephrine (E) and norepinephrine (NE) for VMA and dopamine for HVA, respectively.
Simple and rapid liquid-chromatographic method for the simultaneous measurement of vanillylmandelic acid and homovanillic acid [Tech Brief].