homozygote

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homozygote

(hō'mōzī`gōt): see geneticsgenetics,
scientific study of the mechanism of heredity. While Gregor Mendel first presented his findings on the statistical laws governing the transmission of certain traits from generation to generation in 1856, it was not until the discovery and detailed study of the
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.

Homozygote

 

a cell or an organism in whose genetic makeup the homologous chromosomes carry the identical form of a given gene. A homozygote originates during the fusion of gametes that are identical for a given gene. The genetic formula of a diploid organism homozygous for allele A or a can be written in the form AA or aa; for a triploid organism, AAA or aaa; and so forth.

homozygote

[¦hō·mə′zī‚gōt]
(genetics)
An individual who has identical alleles at one or more loci and therefore produces identical gametes with respect to these loci.
References in periodicals archive ?
Regions of homozygosity identified by SNP microarray analysis aid in the diagnosis of autosomal recessive disease and incidentally detect parental blood relationships.
The levels of HLA-B27 homozygosity were not significantly different to the general population (p=0.
Scientists might be able to control the lingering cancer risk from homozygosity by simply checking whether any newly created stem cells have matching copies of known cancer-related genes.
Comparably high proportions (97 to 100 percent) of seven Chinese aboriginal populations possessed at least one ADH1C*1 allele, although the rates of homozygosity for ADH1C*1 were more variable (59 to 99 percent) in these populations (Chen et al.
Genotype analysis for the two children demonstrated homozygosity for [[beta].
In humans, sickle cell anemia is a life-threatening disease based upon the homozygosity of an altered hemoglobin allele.
They also identify long contiguous stretches of homozygosity, which may suggest an increased likelihood for a recessive condition or uniparental disomy (UPD).
Population genetic indices, including gene homozygosity (Ho), gene heterozygosity (He), effective allele numbers (Ne), and polymorphism information content (PIC) were calculated according to Nei and Roychoudhury (Nei and Roychoudhury, 1974).
In four families, confirmation of the clinical diagnosis was requested, where some of the clinical features were not entirely consistent with homozygosity for sickle cell anaemia.
Meta-analysis of 18 genetic association studies indicated that intron 4a allele, homozygosity for intron 4a of eNOS a/b are positively associated with preeclampsia (8).
Gene sequencing revealed homozygosity for a novel c760C>T (Pro254Ser) mutation in the MTHFR gene.