Degeneration

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Related to hyalinosis: malalignment, transvesical

degeneration

1. Biology the loss of specialization, function, or structure by organisms and their parts, as in the development of vestigial organs
2. Biology
a. impairment or loss of the function and structure of cells or tissues, as by disease or injury, often leading to death (necrosis) of the involved part
b. the resulting condition
3. Electronics negative feedback of a signal

Degeneration

 

(biology). (1) In morphology, the process of cell or organ destruction; for example, the disappearance of the tail in the tadpole when it is transformed into a frog.

(2) In microbiology, the attenuation of the viability of a culture of unicellular organisms under unfavorable growth conditions.

(3) The concepts of general and specific degeneration were introduced into the theory of evolution by A. N. Severtsov. By general degeneration, or morphophysiological regression, Severtsov meant one of the trends of the evolutionary process, characterized by a reduction of the organs with active functions (organs of locomotion, sense organs, the central nervous system) and the progressive development of organs that are passive but important for the animal’s survival (the sexual system and the passive means of defense, such as integuments and protective coloration). The development of tunicates, cirripeds, and tapeworms proceeded according to the principle of general degeneration. In specific degeneration, organs present in the ancestors are reduced in the process of an organism’s historical development: for example, the extremities in legless lizards and the shell in cephalopods. The cause of the reduction of organs is the absence of the conditions necessary for their development and functioning.

(4) In pathology, the term “degeneration” was introduced by R. Virchow, who admitted the possibility of the “degeneration” of cells. Present-day medicine has established that changes in cells depend on local or general metabolic disturbance, or dystrophy.


Degeneration

 

a change in the structure and/or function of cells and tissues as a result of certain diseases. The term “degeneration” was introduced into the language of general pathology by R. Virchow to designate processes in which the normal components of the cytoplasm are displaced and in which unnecessary or harmful deposits form in the intercellular matter. The deposits include protein-like substances, fatlike substances (in which case the deposition process is called lipoidosis), and calcium salts. In Soviet medical literature these pathological processes, which Virchow called degenerations, are conventionally termed dystrophies.

In some medical disciplines, “degeneration” has a specific meaning. For example, in neuropathology it usually refers to decomposition of the nerve fiber as a result of injury or death of the corresponding neuron.

degeneration

[di‚jen·ə′rā·shən]
(electronics)
The loss or gain in an amplifier through unintentional negative feedback.
(medicine)
Deterioration of cellular integrity with no sign of response to injury or disease.
General deterioration of a physical, mental, or moral state.
(statistical mechanics)
A phenomenon which occurs in gases at very low temperatures when the molecular heat drops to less than ³⁄₂ the gas constant.
References in periodicals archive ?
The number of patients with diabetic nephropathy and arteriolar hyalinosis was limited (11 and 19, respectively).
Buyukgebiz B, Ozturk Y, Arslan N, Ozer E: A rare cause of protein-losing enteropathy and growth retardation in infancy: infantile systemic hyalinosis.
The process of hyalinosis invariably also affects the glomerular arteriole in moderately advanced diabetic nephropathy.
The authors' objective was to present the phenotype characteristics of infantile systemic hyalinosis with a particular focus on oral lesions, and obstacles in the therapeutic management in the case reported.
In time, the glomeruli show segmental sclerosis and hyalinosis followed by global sclerosis.
25,26) The vascular compartment should be examined for the presence of intimal fibrosis, fibrinoid necrosis or vasculitis, intraluminal thrombi, atheroemboli, or hyalinosis.
Microscopically, most glomeruli are globally sclerotic with or without hyalinosis, and they do not reveal the primary disease.
FSGS, defined by segmental solidification of the tuft, occasionally accompanied by hyalinosis, foam cells or adhesion to the Bowman capsule, and decreased number of podocytes (podocytopenia; Figures 2, B, and 4);
In FSGS perihilar variant the segmental sclerotic lesion is located at the vascular pole and often accompanied by hyalinosis (Figure 6).
Hyaline caps and capsular drops, as well as hyalinosis in afferent and efferent arterioles are features characteristic of diabetic nephropathy.
In our experience, segmental glomerular sclerosis, and in particular hyalinosis, may develop in patients who have been treated for a prolonged time (more than 1 year) with bevacizumab (Figure 1, C).