Hydatiform Mole

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hydatiform mole

[hī′dad·ə‚fȯrm ′mōl]
A benign placental tumor formed as a cystic growth of the chorionic villi. Also known as hydatiform tumor.

Hydatiform Mole


an abnormal pregnancy resulting from a pathologic ovum with proliferation of the epithelium of the chorion frondosum and edema of the stroma of the villi. The causes of a hydatiform mole are not known. Externally it resembles a grape cluster, since it is a cluster of variously sized cysts with transparent contents.

When there is a hydatiform mole and changes in the villi are widespread, the fetus most often dies; however, even after the death of the fetus the mole continues to develop. As a result of proliferation of the vesicles, the uterus enlarges comparatively rapidly, and its size does not correspond to the term of the pregnancy. One of the principal symptoms of a hydatiform mole is the appearance in the third or fourth month of pregnancy of bloody discharges and hemorrhages from the genital tract, which result from the partial sloughing off of cysts from the uterine walls. The blood is watery and dark in color and contains the rejected cysts of the mole. Hemorrhage leads to considerable anemia and may endanger the woman’s life if intensified.

Often when there is a hydatiform mole, symptoms of late toxemia of pregnancy appear as early as the first half of the pregnancy. In the rare invasive form of hydatiform mole the cysts deeply penetrate the musculature of the uterus, which may lead to perforation of the uterus and severe intra-abdominal hemorrhage. The greatest danger of an hydatiform mole is the possible development of a malignant tumor, that is, a chorionepithelioma.

Treatment includes the use of preparations that contract the uterus. The cysts of the mole can also be sucked out with a special vacuum apparatus. After removal of a hydatiform mole the woman remains under a doctor’s care for 1½ to two years.


References in periodicals archive ?
Complete hydatidiform mole with retained maternal chromosomes 6 and 11.
3) Theca lutein cysts are associated with complete hydatidiform moles 14% to 30% of the time.
False-negative pregnancy test in hydatidiform mole.
Based on both morphologic and cytogenetic criteria, two syndromes of hydatidiform mole have been described: partial and complete.
Keywords: Gestational trophoblastic disease, Hydatidiform mole, P57KIP2 IHC.
Keywords: Hydatidiform mole, Minisatellite, Variable Number Tandem Repeats, Genotyping technique
The concept of benign metastasizing hydatidiform moles.
Keywords: Partial hydatidiform mole, Pregnancy, Recurrent molar pregnancy.
Immunohistochemistry for the imprinted gene product IPL/PHLDA2 for facilitating the differential diagnosis of complete hydatidiform mole.
com), which provides information, links, references and support groups for anyone who has suffered a molar pregnancy; Hydatidiform Mole and Choriocarcinoma UK Information and Support Service (www.
She was 13 weeks pregnant when a visit to her ob-gyn revealed she had a hydatidiform mole, a pregnancy-related chromosomal mix-up that results in a benign tumor.