hydrazone


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hydrazone

[′hī·drə‚zōn]
(organic chemistry)
A compound containing the grouping ‒NH·N:C‒, and obtained from a condensation reaction involving hydrazines with aldehydes or ketones; has been used as an exotic fuel.
References in periodicals archive ?
Briefly, we stained proteins with Sypro Ruby membrane stain according to the manufacturer's instructions (Bio-Rad) followed by the detection of hydrazone groups with an antidinitrophenyl antibody (Dako, V0401).
In view of these, we report here the synthesis of aryl hydrazone pyrazoline-5-one containing different substituted thiazole moieties.
Succinimidyl 4-hydrazinonicotinate acetone hydrazone (SANH) and a 5'-aldehyde-modified (CHO) oligodeoxynucleotide (ODN) were from Solulink.
SGN-15 is a first-generation antibody-drug conjugate (ADC) that utilizes a hydrazone linker to target the cell-killing drug doxorubicin to tumor tissues expressing a Lewis-Y-related antigen.
The hydrogen peroxide reacts with 3-methyl-2-benzothiazolinone hydrazone and 3-(dimethylamino) benzoic acid in the presence of peroxidase to yield an indamine dye, which has an absorbance maximum at 590 run.
These intermediates were treated with aqueous acid, which hydrolyzed the carbo-tert-butoxy ester, and the resulting N-carboxylic acid underwent decarboxylation to free the hydrazone, which was immediately protonated to the hydrazonium hydrochloride.
Li Synthesis of Some Novel Hydrazone Derivatives as Antifungal Agents.
Seattle Genetics conducted studies showing that ADCs prepared with hydrazone linkers for acid-mediated drug release were highly active in vitro and in vivo, yet demonstrated instability in human and mouse plasma.