Jean Charles Piette presented a separate prospective study that demonstrated for the first time that hydroxychloroquine
crosses the placenta to produce nearly identical serum concentrations in the fetus and the mother.
It is hypothesized that autophagy is protective in the setting of arginine deprivation and that inhibition of autophagy by hydroxychloroquine
(ChQ) would increase cell death.
In fact, hydroxychloroquine
is undergoing a rebirth of sorts, according to Dr.
is best known as a treatment for malaria, but the drug is also classified as a slow-onset disease-modifying antirheumatic drug (DMARD) administered in tablet form as a first-line therapy for systemic lupus erythematosus, rheumatoid arthritis and sarcoidosis.
Further analysis of DMARDs showed that the individual incident rate ratio for hydroxychloroquine
, methotrexate, and sulfasalazine vs.
The study enrolled 100 patients with rheumatoid arthritis (RA) of less than 1 year's duration from 15 centers, randomizing them to receive methotrexate, sulfasalazine, hydroxychloroquine
, and prednisone plus either infliximab or placebo for 6 months.
a privately held biotechnology company, today announced the program advancement of APT's proprietary formulation of hydroxychloroquine
(HCQ) into Phase 2 clinical trials.
Based on their literature review, the researchers found that combining prednisone with hydroxychloroquine
, methotrexate, or sulfasalazine works better than using only a synthetic DMARD to reduce joint swelling and tenderness and to improve function.
The study is randomized, so half of the participants will receive atorvastatin, hydroxychloroquine
(a treatment commonly used for lupus patients), low dose aspirin, folate and dietary counseling, in addition to their standard lupus treatments.
Karen Newell's Metabolic Disruption Technology compounds, hydroxychloroquine
(HCQ), in combination with an existing cancer drug, sorafenib (marketed as Nexavar (TM)).
There are currently only three medications approved for the treatment of lupus; hydroxychloroquine
, aspirin, and prednisone, highlighting the significant unmet need.
Tenders are invited for Supply of Cap / Tab Hydroxychloroquine