The company's clinical programs include VK5211, an orally available, non-steroidal selective androgen receptor modulator, or SARM, in Phase 2 development for the treatment and prevention of lean body mass loss in patients who have undergone hip fracture surgery, VK2809, a small molecule thyroid beta agonist entering Phase 2 development for hypercholesterolemia
and fatty liver disease, and VK0612, a first-in-class, orally available drug candidate in Phase 2 development for type 2 diabetes.
120 patients with hypercholesterolemia
with very high LDL- Cholesterol levels, have premature coronary artery diseases in second and third decades of life, were compared with twenty controls .
It also reviews key players involved in the therapeutic development for Familial Hypercholesterolemia
(Type II Hyperlipoproteinemia).
2b) at which could be cause of severe hypercholesterolemia
in these patients.
The aim of this study is to evaluate the effect of risk factors on atherosclerotic changes of aortic wall and valve in patients with and without non-familial hypercholesterolemia
by transthoracic echocardiography (TTE).
alone was associated with a 1.
in subject 11-3 is currently unexplained.
Approximately 4 million people in the United States have a genetic predisposition to lipid disorders, such as familial hypercholesterolemia
, familial combined hyperlipidemia, and polygenic hypercholesterolemia
Wilson and his colleagues received approval last year from the National Institutes of Health's Recombinant DNA Advisory Committee (RAC) to administer liver cells containing added LDL receptor genes to three patients with familial hypercholesterolemia
(SN: 10/12/91, p.
Coverage of the Hypercholesterolemia
pipeline on the basis of route of administration and molecule type.
They will examine and test approaches to discussing familial hypercholesterolemia
genomic sequencing results with patients and families, and also how family members communicate with one another.
Lowering LDL-C remains the primary objective for the management of hypercholesterolemia
and has been supported by numerous morbidity and mortality trials.