B and C, In contrast, pleomorphic lobular carcinoma cells display significant nuclear pleomorphism, abundant eosinophilic cytoplasm, nuclear hyperchromasia
, nuclear membrane irregularities, and prominent nucleoli.
Histopathology identified polyhedral epithelial cells arranged in sheets and strands that exhibited nuclear pleomorphism and variable hyperchromasia
There was loss of cellular architecture, nuclear duplication and increased infiltration of leucocytes with prominent hyperchromasia
in animals subjected to high fructose fluid intake as well as isoproterenol (Fig.
Injury to the respiratory cells resulted in distortion of the alveolar architecture such as morphologic changes characterized by cell flattening/stretching, hyperchromasia
, and cellular death.
11) Nevertheless, there are some histologic findings that may assist in the diagnosis: aggregates of lymphoid infiltrates, poor circumscription of the dermal infiltrate, subtle pleomorphism, and hyperchromasia
with an associated lentiginous melanocytic proliferation.
Secondary cellular changes can include nuclear hypertrophy, hyperchromasia
and pleomorphism, fat necrosis.
After 72 hours the PA treated cells showed evidence of scant cytoplasm and hyperchromasia
when compared to control.
A, The myxoid/vascular pattern shows spindled myofibroblasts, which usually lack clear nuclear hyperchromasia
Several fibrous septa containing atypical stromal cells with hyperchromasia
were also noted.
In contrast, the use of PAP staining is recommended for the cervix and vaginal tissue, (2) no significant difference was observed in ovaries, uterus, and fallopian tubes compared to the control group, (3) treatment with DHEA induced nuclear hyperchromasia
of c ervical cells compared to DHEA E and control, (4) the use of DHEA alone or in combination induced an increase in mitotic ability of the vaginal tissue in comparison to the control, and (5) the treatment with DHEA or DHEA E resulted in occasional hyperchromatic nuclear condition compared to the control group.
While syncytial HSIL is characterized by hyperchromatic crowded groups, typically composed of epithelial cells exhibiting nuclear hyperchromasia
associated with variations in nuclear size and shape as well as irregular nuclear membranes, invasive adenocarcinoma is typically characterized by syncytial/3-dimensional groups, as well as single atypical glandular cells with vacuolated cytoplasm and enlarged pleomorphic nuclei with macronucleoli.
Morp hological criteria include: nuclear to cytoplasmic ratio (N/C ratio), regularity of the nuclear membranes, nuclear vacuolization, nuclear enlargement, hyperchromasia
, cytoplasmic vacuolization, cytoplasmic enlargement, overall cell shape and size, cellular hypertrophy, and cytoplasmic angulations/processes.