hyperchromatic


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hyperchromatic

[¦hī·pər·krō′mad·ik]
(biology)
Staining more intensely than normal.
References in periodicals archive ?
The cells of the tumor display a basaloid appearance with angulated, hyperchromatic nuclei and scant, clear to eosinophilic cytoplasm.
The cells had a lymphoid aspect and rounded and hyperchromatic nuclei and were arranged in nests with clearly visible tropism for the vessel wall (figure 2, A).
Pigment-synthesizing melanoma is characterized by a dome-shaped proliferation of heavily pigmented epithelioid and spindle melanocytes with abundant cytoplasm, large vesicular or hyperchromatic nuclei, and a single prominent eosinophilic nucleolus.
Focal confluent growth of melanocytes was present in the suprapapillary plates, and focal atypia, characterized by larger irregular hyperchromatic nuclei, was present.
Histologically it was composed of monomorphic small round cells with scant cytoplasm and hyperchromatic round nucleus (Fig.
In contrast, oncocytomas only have eosinophilic cells with round, hyperchromatic nuclei arranged in a nested or tubular pattern.
The basal layer is focally palisaded, with hyperchromatic nuclei.
Cytologic criteria were Nuclear morphology (Large nuclei, Anisonucleosis, Hyperchromatic nuclei, Vesicular nuclei, Chromatin clumping, Prominent nucleoli, Multiple nucleoli), and Cellular morphology (Comet cells, Signet ring cells, Vacuolar cytoplasm, Granular cytoplasm, Apocrine cells, Ractive ductal cells, Squamous cells).
They are well-differentiated and lack increased mitotic figures and atypical, pleomorphic or hyperchromatic nuclei.
The degree of lymphoid atypia is variable among cases; however, neoplastic cells are commonly pleomorphic with hyperchromatic, irregular nuclei surrounded by a rim of palestaining cytoplasm.
The diagnosis of LCS is based on the following: malignant cytological features, such as atypia, hyperchromatic nuclei, prominent nucleoli, and frequent mitotic figures; the appearance of typical Birbeck granules; a typical immunophenotype with consistent expression of CD la and S-100 protein, and langerin.
The cells ranged in size with scant and fragile cytoplasm, high nuclear/cytoplasmic ratios, hyperchromatic, angulated nuclei showing nuclear molding, focal pseudorosette formations, granular chromatin and inconspicuous nucleoli and some mitotic figures.