hyperchromatic


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hyperchromatic

[¦hī·pər·krō′mad·ik]
(biology)
Staining more intensely than normal.
References in periodicals archive ?
HPE of Skin Section showing Disarray of Keratinocytes with Atypical Hyperchromatic Nuclei, Loss of Polarity of Cells in the Malpighian Layer.
Caption: Figure 2: (a) Cytology of the nodules showing anisokaryosis, hyperchromatic and stippled nuclei, prominent nucleoli, intranuclear inclusions, and pigment laden macrophages (H and E; x 100), (b) histopathology showing pleomorphic tumor cells with pleomorphic round to oval nuclei, prominent eosinophillic nucleoli, multinucleate giant cells with intracytoplasmic melanin pigment and atypical mitotic figures (H&E; X100).
According to the microscopic examination the tumor node consisted of atypical squamous epithelial cells, with hyperchromatic irregular nuclei, and disturbed nucleo-cytoplasmic relationship with obvious pathological mitoses, arranged in irregular strips and nests.
The malignancy showed a range of morphologic appearances, with some areas of solid and epithelioid pattern resembling a poorly differentiated carcinoma and other areas showing more pronounced vascular differentiation with anastomosing, angular, blood-filled spaces lined by elongated hyperchromatic tumour cells (Figs.
Histopathology showed small atypical cells with darkly staining, hyperchromatic and pleomorpic nuclei.
The ischemia group had numerous pyramidal cells with pyknotic nuclei, lack of nucleolus, and hyperchromatic cytoplasm compared to cells of the control group (Figure 6(b)).
Microscopically, the tumor consisted of spindle cells arranged in bundles or incidentally, with elongated, oval, or thickened, hyperchromatic nuclei, with pleomorphism.
Histopathology of the nodular lesion revealed stratified squamous epithelium, within the dermis there was collection of cells with hyperchromatic nuclei with prominent nucleoli (Figure 2).
The neoplastic cells varied from spindle to pleomorphic with basophilic cytoplasm, hyperchromatic nuclei, and multiple nucleoli (Fig 2B).
For example, in mild dysplasia, where the nuclear-cytoplasmic ratio was shifted more in favor of the nucleus, the contours of the nuclei were irregular chromatin, was moderately hyperchromatic, and had a grainy appearance.
The pancreatic aspirate consisted of cohesive clusters of malignant epithelial cells; the cells were arranged in a streaming fashion, the nuclei were hyperchromatic with coarse chromatin, and keratinization was evident on the Papanicolaou-stained smear (Figure 4).
Tumor cells of appendiceal origin feature low-grade differentiation and may be elongated and hyperchromatic.