hyperchromatism


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hyperchromatism

[‚hī·pər′krō·mə‚tiz·əm]
(pathology)
Excessive pigment formation in the skin.
A condition in which cells or parts of cells stain more intensely than is normal.
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NUMEROUS KERATIN PEARLS AND FEW MITOTIC FIGURES WITH CELLULAR AND NUCLEAR PLEOMORPHISM AND HYPERCHROMATISM WEREALSO SEEN, ADIAGNOSIS OF WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA WAS GIVE (H&E 20X).
Some areas of cystic lining epithelium shows dysplastic features like nuclear hyperchromatism and altered nuclear cytoplasmic ratio.
There might be slight hyperchromatism, but chromatin is uniformly and finely granulated and free of major chromatin abnormalities (figure 2).
Thus, were observed damage of total architectonics of liver, microcirculation disturbances, cellular polymorphism, destruction of border plane; incompletion of hepatocytes, fat, hydropic and balloon dystrophy of hepatocytes, lipofuscinosis of hepatocytes, nidus hepatonecrosis, hyperchromatism and polychromatism, degeneration (vacuolization) of hepatocytes' nuclei, intralobular lymphoplasmocytic infiltration, pericentral lymphoid infiltration.
7) The criteria of atypia included the presence of the major malignant features including; nuclear enlargement associated with increased nuclear cytoplasmic ratio, hyperchromatism, chromatin clumping with moderately prominent nucleolation and irregular nuclear borders, bi or multinuclation, and scantiness of the cytoplasm and variations in size and/or shape of the cells and nuclei.
A juxtacortical chondroma must be differentiated from a juxtacortical (or periosteal) chondrosarcoma, particularly as a juxtacortical chondroma often demonstrates high cellularity, binucleated cells, hyperchromatism and a myxoid appearance.
On histologic analysis, unlike in leiomyosarcomas, the absence of mitotic figures, pleomorphism and hyperchromatism are the usual features.
It can also be seen in some of these islands the presence of squamous metaplasia, peripheral cells arranged in palisade exhibiting hyperchromatism and cores of reverse polarity.
At higher magnification, some chondrocytes showed foci of slight nuclear hyperchromatism.
The histologic finding of ASL in our patient (Figure 1) shows large vascular spaces lined with atypical vascular epithelium and with polymorphism and hyperchromatism of cells.
Because neoplastic cells display nuclear enlargement and hyperchromatism, reflecting a decreased DNA content, flow cytometry samples are compared with healthy control cells and the amount of DNA is displayed in a histogram as diploid, tetraploid, and aneuploid.
Despite polyp formation, cellular crowding, hyperchromatism, and mitotic activity do not occur in the upper zones of the crypts.