hypergammaglobulinemia


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hypergammaglobulinemia

[¦hī·pər‚gam·ə¦gläb·yə·lə′nē·mē·ə]
(medicine)
Increased blood levels of gamma globulin, usually associated with hepatic disease.
References in periodicals archive ?
Autoimmune pancreatitis is a chronic inflammatory disorder of unknown etiology associated with hypergammaglobulinemia that leads to fibrosis and organ dysfunction.
Hypergammaglobulinemia and musculoskeletal manifestations are common findings in both JIA and FMF even though these diseases have different pathogenesis.
Gaucher disease can be associated with hyperactivity of the immune system, which manifests with polyclonal hypergammaglobulinemia or mono-clonal gammopathies (11).
and European sera," (7,p159) for example "sticky sera" or hypergammaglobulinemia (see their Table 8.
Visceral leishmaniasis is a systemic form of the disease that can present more than a year after exposure with fever, hepatosplenomegaly, cytopenias, and hypergammaglobulinemia.
Plasma cell infiltrates Florid plasma cell expansion in lymph nodes, tissues and bone marrow with polyclonal hypergammaglobulinemia HHV8-associated pathologies MCD MCD with so-called microlymphoma MCD with lymphoma MCD with Kaposi's sarcoma MCD with HHV8 associated haemophagocytic syndrome Lymphomas specifically occurring in HIV-positive patients Plasmablostic lymphoma Primary effusion lymphoma--classical and 'solid' forms Lymphomas orising in MCD Lymphomas occurring In other immunodeficient states Lesions similar to polymorphic post-transplant lymphoproliferative disorder Lymphomas also occurring In immune competent patients Classical Hodgkin's lymphoma Burkitt's lymphoma Diffuse large B-cell lymphoma MCD, multicentric Castleman's disease.
Patients may have a benign hypergammaglobulinemia associated with an increased erythrocyte sedimentation rate (ESR).
VLM is characterized by persistent eosinophilia, bronchial asthma, leucocytosis, urticaria fever, hepatomegaly, pyogenic liver abscess, and hypergammaglobulinemia.
Studies with nonautoimmune-prone animal models suggest that the immunoactivating properties of mercury can be divided into three major pathologic sequelae: lympho-proliferation, hypergammaglobulinemia, and the development of systemic autoimmunity manifested as production of autoantibody and immune-complex disease (8,15).
altered the balance between Th2 and Th1 cytokine production, suppressed hypergammaglobulinemia, and prevented the [kidney complications seen] in chronic GVHD.
Increased lactate dehydrogenase (LDH) and lysozyme activity has been reported, and polyclonal hypergammaglobulinemia is present in about 30% of cases.
A significantly greater percentage of belimumab-treated patients with hypergammaglobulinemia at baseline achieved normalization of IgG at Week 52 (p<0.