hypergammaglobulinemia


Also found in: Dictionary, Medical, Wikipedia.

hypergammaglobulinemia

[¦hī·pər‚gam·ə¦gläb·yə·lə′nē·mē·ə]
(medicine)
Increased blood levels of gamma globulin, usually associated with hepatic disease.
References in periodicals archive ?
Serum protein electrophoresis showed non-monoclonal hypergammaglobulinemia (IgG level, 6190 mg/dL), while urine protein electrophoresis showed non-monoclonal increase in globulins (alpha-1-globulin, 3.
The complex mixture of cytokines secreted by these cells including IL-4, IL-5 and IL-13 explain two clinical findings in AD patients: hypereosinophilia (linked to the hyperproduction of IL-5) and hypergammaglobulinemia E (linked to the IL-4) [7, 8].
Visceral Leishmaniasis (VL), also known as kala-azar, is usually caused by Leishmania (Leishmania) chagasi, and is characterized by fever, hepatosplenomegaly, pancytopenia, substantial weight loss, and hypergammaglobulinemia.
AIP was first described in 1961 by Sarles et al as pancreatitis with hypergammaglobulinemia.
Laboratory findings may include elevated erythrocyte sedimentation rate, thrombocytopenia, hypergammaglobulinemia, increased urea and creatinine levels, and elevated C-reactive protein.
Hypergammaglobulinemia may also be present in the setting of symptomatic patients, as was also seen in our patient.
Three years later she came back to me with hand swelling, hypergammaglobulinemia, renal tubular acidosis, this time with significantly higher ANA and RF titers, and hypocomplementemia.
Rouleux formation and increased background staining may also be seen; this likely reflects the presence of concomitant hypergammaglobulinemia.
Hypo complementemia due to complement cascade activation is common, as well as hypergammaglobulinemia due to polyclonal B lymphocyte expansion.
The antibodies are directed against salivary duct antigen, increase in [beta]-2 microglobulin in saliva and synovial fluid, general immune abnormalities including hypergammaglobulinemia, rheumatoid factor, antinuclear antibody, anti-DNA (Deoxyribonucleic acid) antibody and increased Erythrocyte Sedimentation Rate levels have been observed (4).