hyperinsulinism


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Related to hyperinsulinism: Hyperinsulinemia

hyperinsulinism,

presence in the system of an above-normal amount of insulininsulin,
hormone secreted by the β cells of the islets of Langerhans, specific groups of cells in the pancreas. Insufficiency of insulin in the body results in diabetes. Insulin was one of the first products to be manufactured using genetic engineering.
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, the substance secreted by the pancreaspancreas
, glandular organ that secretes digestive enzymes and hormones. In humans, the pancreas is a yellowish organ about 7 in. (17.8 cm) long and 1.5 in. (3.8 cm) wide. It lies beneath the stomach and is connected to the small intestine at the duodenum (see digestive system).
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 and needed by the body to utilize sugar. An increased amount of insulin in the body results in below-normal amounts of sugar in the system, giving rise to such symptoms as headache, dizziness, weakness, and emotional instability. In severe cases there may be convulsions, coma, and death. The cause of oversecretion of insulin may be organic, i.e., a tumor of the pancreas, impaired liver function, or endocrine disorders, or it may be functional, e.g., unusual muscular exertion, pregnancy, or lactation. In diabetics, hyperinsulinism is known as insulin shock and may occur from overdosage with insulin in the course of treatment. Where there is some organic cause for hyperinsulinism, surgery may be required to eliminate it. Functional hyperinsulinism and insulin shock are treated by dietary measures designed to bring the insulin-sugar ratio into better balance.

hyperinsulinism

[‚hī·pər′in·sə·lə‚niz·əm]
(medicine)
Condition caused by abnormally high levels of insulin in the blood.
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References in periodicals archive ?
In congenital hyperinsulinism the mutant gene causes the structure of the protein to change.
Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.
16) and described a hyperinsulinism modification plan.
Dr Bin Sabt told Gulf News that congenital hyperinsulinism is the most frequent cause of severe, persistent hypoglycaemia in newborns and children.
Acute hyperinsulinism raises plasma interleukin-6 in both non diabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index.
Contribution of total and intact proinsulins to hyperinsulinism in subjects with obesity, impaired glucose tolerance or type 2 diabetes.
Other diseases of connection to Ashkenazi Jews are Familial Hyperinsulinism, Joubert Syndrome Type 2, Lipoamide Dehydrogenase Deficiency (E3), Nemaline Myopathy, Spinal Muscular Atrophy (SMA), Usher Syndrome Type 3, Usher Syndrom Type I, and Walker Warburg Syndrome.
12 HbA1c changes may not be so sensitive as to reflect slight but recurrent episodes of hyperglycemia, which may nevertheless be enough to cause fetal hyperinsulinism and hypoglycemia.
During the menopausal transition there is an emergence of features related to MetS which in turn increase CVD risk, such as obesity, atherogenic lipid profiles, diabetes mellitus, hyperinsulinism and hypertension [1].
Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate.